Overview
| Uniprot ID | P23142 |
|---|
| Protein Name | Fibulin-1 |
|---|
| Gene Name | FBLN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 59 |
LPYATESKECRMVQE |
| 649 |
RDSFDIIKRYMDGMT |
Function
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP
Protein Sequence
10
MERAAPSRRV
20
PLPLLLLGGL
30
ALLAAGVDAD
40
VLLEACCADG
50
HRMATHQKDC
60
SLPYATESKE
70
CRMVQEQCCH
80
SQLEELHCAT
90
GISLANEQDR
100
CATPHGDNAS
110
LEATFVKRCC
120
HCCLLGRAAQ
130
AQGQSCEYSL
140
MVGYQCGQVF
150
QACCVKSQET
160
GDLDVGGLQE
170
TDKIIEVEEE
180
QEDPYLNDRC
190
RGGGPCKQQC
200
RDTGDEVVCS
210
CFVGYQLLSD
220
GVSCEDVNEC
230
ITGSHSCRLG
240
ESCINTVGSF
250
RCQRDSSCGT
260
GYELTEDNSC
270
KDIDECESGI
280
HNCLPDFICQ
290
NTLGSFRCRP
300
KLQCKSGFIQ
310
DALGNCIDIN
320
ECLSISAPCP
330
IGHTCINTEG
340
SYTCQKNVPN
350
CGRGYHLNEE
360
GTRCVDVDEC
370
APPAEPCGKG
380
HRCVNSPGSF
390
RCECKTGYYF
400
DGISRMCVDV
410
NECQRYPGRL
420
CGHKCENTLG
430
SYLCSCSVGF
440
RLSVDGRSCE
450
DINECSSSPC
460
SQECANVYGS
470
YQCYCRRGYQ
480
LSDVDGVTCE
490
DIDECALPTG
500
GHICSYRCIN
510
IPGSFQCSCP
520
SSGYRLAPNG
530
RNCQDIDECV
540
TGIHNCSINE
550
TCFNIQGGFR
560
CLAFECPENY
570
RRSAATLQQE
580
KTDTVRCIKS
590
CRPNDVTCVF
600
DPVHTISHTV
610
ISLPTFREFT
620
RPEEIIFLRA
630
ITPPHPASQA
640
NIIFDITEGN
650
LRDSFDIIKR
660
YMDGMTVGVV
670
RQVRPIVGPF
680
HAVLKLEMNY
690
VVGGVVSHRN
700
VVNVHIFVSE
YWF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005604 |
basement membrane |
| Cellular Component |
GO:0071953 |
elastic fiber |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005201 |
extracellular matrix structural constituent |
| Molecular Function |
GO:0070051 |
fibrinogen binding |
| Molecular Function |
GO:0001968 |
fibronectin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0016504 |
peptidase activator activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0072378 |
blood coagulation, fibrin clot formation |
| Biological Process |
GO:0007566 |
embryo implantation |
| Biological Process |
GO:0030198 |
extracellular matrix organization |
| Biological Process |
GO:0007162 |
negative regulation of cell adhesion |
| Biological Process |
GO:2000146 |
negative regulation of cell motility |
| Biological Process |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0001933 |
negative regulation of protein phosphorylation |
| Biological Process |
GO:2000647 |
negative regulation of stem cell proliferation |
| Biological Process |
GO:1900025 |
negative regulation of substrate adhesion-dependent cell spreading |
| Biological Process |
GO:1904188 |
negative regulation of transformation of host cell by virus |
| Biological Process |
GO:0071635 |
negative regulation of transforming growth factor beta production |
| Biological Process |
GO:0048146 |
positive regulation of fibroblast proliferation |
| Biological Process |
GO:0010628 |
positive regulation of gene expression |
| Biological Process |
GO:1904237 |
positive regulation of substrate-dependent cell migration, cell attachment to substrate |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.