Search Results

Overview

Uniprot IDP23193
Protein NameTranscription elongation factor A protein 1
Gene NameTCEA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
117 SGNVSNRKDETNARD
19 MDKMVQKKNAAGALD
202 ISNLKDAKNPNLRKN
242 EMRKNLTKEAIREHQ
252 IREHQMAKTGGTQTD
55 MSVNAIRKQSTDEEV
84 LDGPSTEKDLDEKKK
89 TEKDLDEKKKEPAIT

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus

Protein Sequence

10 MEDEVVRFAK 20 KMDKMVQKKN 30 AAGALDLLKE 40 LKNIPMTLEL 50 LQSTRIGMSV 60 NAIRKQSTDE 70 EVTSLAKSLI 80 KSWKKLLDGP 90 STEKDLDEKK 100 KEPAITSQNS 110 PEAREESTSS 120 GNVSNRKDET 130 NARDTYVSSF 140 PRAPSTSDSV 150 RLKCREMLAA 160 ALRTGDDYIA 170 IGADEEELGS 180 QIEEAIYQEI 190 RNTDMKYKNR 200 VRSRISNLKD 210 AKNPNLRKNV 220 LCGNIPPDLF 230 ARMTAEEMAS 240 DELKEMRKNL 250 TKEAIREHQM 260 AKTGGTQTDL 270 FTCGKCKKKN 280 CTYTQVQTRS 290 ADEPMTTFVV 300 CNECGNRWKF C

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005669 transcription factor TFIID complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003711 transcription elongation factor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006368 transcription elongation by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.