Search Results
Overview
| Uniprot ID | P23198 |
|---|---|
| Protein Name | Chromobox protein homolog 3 |
| Gene Name | Cbx3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | KQNGKSKKVEEAEPE |
| 5 | ***MASNKTTLQKMG |
| 92 | EKDGTKRKSLSDSES |
Function
Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (By similarity). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (By similarity). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0061793 | chromatin lock complex |
| Cellular Component | GO:0010369 | chromocenter |
| Cellular Component | GO:0000775 | chromosome, centromeric region |
| Cellular Component | GO:0000779 | condensed chromosome, centromeric region |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0035985 | senescence-associated heterochromatin focus |
| Cellular Component | GO:0090734 | site of DNA damage |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0160267 | histone H1K26me1 reader activity |
| Molecular Function | GO:0160268 | histone H1K26me2 reader activity |
| Molecular Function | GO:0062072 | histone H3K9me2/3 reader activity |
| Molecular Function | GO:1990226 | histone methyltransferase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0048511 | rhythmic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.