Overview
| Uniprot ID | P23219 |
|---|
| Protein Name | Prostaglandin G/H synthase 1 |
|---|
| Gene Name | PTGS1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 545 |
ICSPEYWKPSTFGGE |
Function
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity)
Protein Sequence
10
MSRSLLLWFL
20
LFLLLLPPLP
30
VLLADPGAPT
40
PVNPCCYYPC
50
QHQGICVRFG
60
LDRYQCDCTR
70
TGYSGPNCTI
80
PGLWTWLRNS
90
LRPSPSFTHF
100
LLTHGRWFWE
110
FVNATFIREM
120
LMRLVLTVRS
130
NLIPSPPTYN
140
SAHDYISWES
150
FSNVSYYTRI
160
LPSVPKDCPT
170
PMGTKGKKQL
180
PDAQLLARRF
190
LLRRKFIPDP
200
QGTNLMFAFF
210
AQHFTHQFFK
220
TSGKMGPGFT
230
KALGHGVDLG
240
HIYGDNLERQ
250
YQLRLFKDGK
260
LKYQVLDGEM
270
YPPSVEEAPV
280
LMHYPRGIPP
290
QSQMAVGQEV
300
FGLLPGLMLY
310
ATLWLREHNR
320
VCDLLKAEHP
330
TWGDEQLFQT
340
TRLILIGETI
350
KIVIEEYVQQ
360
LSGYFLQLKF
370
DPELLFGVQF
380
QYRNRIAMEF
390
NHLYHWHPLM
400
PDSFKVGSQE
410
YSYEQFLFNT
420
SMLVDYGVEA
430
LVDAFSRQIA
440
GRIGGGRNMD
450
HHILHVAVDV
460
IRESREMRLQ
470
PFNEYRKRFG
480
MKPYTSFQEL
490
VGEKEMAAEL
500
EELYGDIDAL
510
EFYPGLLLEK
520
CHPNSIFGES
530
MIEIGAPFSL
540
KGLLGNPICS
550
PEYWKPSTFG
560
GEVGFNIVKT
570
ATLKKLVCLN
580
TKTCPYVSFR
590
VPDASQDDGP
AVERPSTEL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0001750 |
photoreceptor outer segment |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| Molecular Function |
GO:0004601 |
peroxidase activity |
| Molecular Function |
GO:0004666 |
prostaglandin-endoperoxide synthase activity |
| Biological Process |
GO:0019371 |
cyclooxygenase pathway |
| Biological Process |
GO:0001516 |
prostaglandin biosynthetic process |
| Biological Process |
GO:0008217 |
regulation of blood pressure |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
PMID: N/A