Search Results
Overview
| Uniprot ID | P23229 |
|---|---|
| Protein Name | Integrin alpha-6 |
| Gene Name | ITGA6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 961 | FSLFAERKYQTLNCS |
Function
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)
Protein Sequence
10
MAAAGQLCLL
20
YLSAGLLSRL
30
GAAFNLDTRE
40
DNVIRKYGDP
50
GSLFGFSLAM
60
HWQLQPEDKR
70
LLLVGAPRAE
80
ALPLQRANRT
90
GGLYSCDITA
100
RGPCTRIEFD
110
NDADPTSESK
120
EDQWMGVTVQ
130
SQGPGGKVVT
140
CAHRYEKRQH
150
VNTKQESRDI
160
FGRCYVLSQN
170
LRIEDDMDGG
180
DWSFCDGRLR
190
GHEKFGSCQQ
200
GVAATFTKDF
210
HYIVFGAPGT
220
YNWKGIVRVE
230
QKNNTFFDMN
240
IFEDGPYEVG
250
GETEHDESLV
260
PVPANSYLGL
270
LFLTSVSYTD
280
PDQFVYKTRP
290
PREQPDTFPD
300
VMMNSYLGFS
310
LDSGKGIVSK
320
DEITFVSGAP
330
RANHSGAVVL
340
LKRDMKSAHL
350
LPEHIFDGEG
360
LASSFGYDVA
370
VVDLNKDGWQ
380
DIVIGAPQYF
390
DRDGEVGGAV
400
YVYMNQQGRW
410
NNVKPIRLNG
420
TKDSMFGIAV
430
KNIGDINQDG
440
YPDIAVGAPY
450
DDLGKVFIYH
460
GSANGINTKP
470
TQVLKGISPY
480
FGYSIAGNMD
490
LDRNSYPDVA
500
VGSLSDSVTI
510
FRSRPVINIQ
520
KTITVTPNRI
530
DLRQKTACGA
540
PSGICLQVKS
550
CFEYTANPAG
560
YNPSISIVGT
570
LEAEKERRKS
580
GLSSRVQFRN
590
QGSEPKYTQE
600
LTLKRQKQKV
610
CMEETLWLQD
620
NIRDKLRPIP
630
ITASVEIQEP
640
SSRRRVNSLP
650
EVLPILNSDE
660
PKTAHIDVHF
670
LKEGCGDDNV
680
CNSNLKLEYK
690
FCTREGNQDK
700
FSYLPIQKGV
710
PELVLKDQKD
720
IALEITVTNS
730
PSNPRNPTKD
740
GDDAHEAKLI
750
ATFPDTLTYS
760
AYRELRAFPE
770
KQLSCVANQN
780
GSQADCELGN
790
PFKRNSNVTF
800
YLVLSTTEVT
810
FDTPDLDINL
820
KLETTSNQDN
830
LAPITAKAKV
840
VIELLLSVSG
850
VAKPSQVYFG
860
GTVVGEQAMK
870
SEDEVGSLIE
880
YEFRVINLGK
890
PLTNLGTATL
900
NIQWPKEISN
910
GKWLLYLVKV
920
ESKGLEKVTC
930
EPQKEINSLN
940
LTESHNSRKK
950
REITEKQIDD
960
NRKFSLFAER
970
KYQTLNCSVN
980
VNCVNIRCPL
990
RGLDSKASLI
1000
LRSRLWNSTF
1010
LEEYSKLNYL
1020
DILMRAFIDV
1030
TAAAENIRLP
1040
NAGTQVRVTV
1050
FPSKTVAQYS
1060
GVPWWIILVA
1070
ILAGILMLAL
1080
LVFILWKCGF
1090
FKRSRYDDSV
1100
PRYHAVRIRK
1110
EEREIKDEKY
1120
IDNLEKKQWI
1130
TKWNENESYS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0035878 | nail development |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043589 | skin morphogenesis |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0034675 | integrin alpha6-beta1 complex |
| Cellular Component | GO:0034676 | integrin alpha6-beta4 complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0031994 | insulin-like growth factor I binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0038132 | neuregulin binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0031589 | cell-substrate adhesion |
| Biological Process | GO:0007044 | cell-substrate junction assembly |
| Biological Process | GO:0010668 | ectodermal cell differentiation |
Reference
PMID: N/A