Search Results
Overview
| Uniprot ID | P23242 |
|---|---|
| Protein Name | Gap junction alpha-1 protein |
| Gene Name | Gja1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 136 | QIEIKKFKYGIEEHG |
Function
Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in the conductive system of ventricular myocardium and heart morphogenesis (PubMed:26403541). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)
Protein Sequence
10
MGDWSALGKL
20
LDKVQAYSTA
30
GGKVWLSVLF
40
IFRILLLGTA
50
VESAWGDEQS
60
AFRCNTQQPG
70
CENVCYDKSF
80
PISHVRFWVL
90
QIIFVSVPTL
100
LYLAHVFYVM
110
RKEEKLNKKE
120
EELKVAQTDG
130
VNVEMHLKQI
140
EIKKFKYGIE
150
EHGKVKMRGG
160
LLRTYIISIL
170
FKSVFEVAFL
180
LIQWYIYGFS
190
LSAVYTCKRD
200
PCPHQVDCFL
210
SRPTEKTIFI
220
IFMLVVSLVS
230
LALNIIELFY
240
VFFKGVKDRV
250
KGRSDPYHAT
260
TGPLSPSKDC
270
GSPKYAYFNG
280
CSSPTAPLSP
290
MSPPGYKLVT
300
GDRNNSSCRN
310
YNKQASEQNW
320
ANYSAEQNRM
330
GQAGSTISNS
340
HAQPFDFPDD
350
SQNAKKVAAG
360
HELQPLAIVD
370
QRPSSRASSR
380
ASSRPRPDDL
EI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030165 | PDZ domain binding |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005922 | connexin complex |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005916 | fascia adherens |
| Cellular Component | GO:0005921 | gap junction |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0015267 | channel activity |
| Molecular Function | GO:0071253 | connexin binding |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0015562 | efflux transmembrane transporter activity |
| Molecular Function | GO:0005243 | gap junction channel activity |
| Molecular Function | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling |
| Molecular Function | GO:1903763 | gap junction channel activity involved in cell communication by electrical coupling |
| Molecular Function | GO:0055077 | gap junction hemi-channel activity |
| Molecular Function | GO:0034634 | glutathione transmembrane transporter activity |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Biological Process | GO:0008016 | regulation of heart contraction |
| Biological Process | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization |
| Biological Process | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization |
| Biological Process | GO:0009268 | response to pH |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0042098 | T cell proliferation |
| Biological Process | GO:0055085 | transmembrane transport |
| Biological Process | GO:0010232 | vascular transport |
| Biological Process | GO:0042311 | vasodilation |
| Biological Process | GO:0042908 | xenobiotic transport |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0007512 | adult heart development |
| Biological Process | GO:0015867 | ATP transport |
| Biological Process | GO:0003294 | atrial ventricular junction remodeling |
| Biological Process | GO:0048514 | blood vessel morphogenesis |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0046849 | bone remodeling |
| Biological Process | GO:0061337 | cardiac conduction |
| Biological Process | GO:0010643 | cell communication by chemical coupling |
| Biological Process | GO:0010644 | cell communication by electrical coupling |
| Biological Process | GO:0045216 | cell-cell junction organization |
| Biological Process | GO:0007267 | cell-cell signaling |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0071467 | cellular response to pH |
| Biological Process | GO:0002544 | chronic inflammatory response |
| Biological Process | GO:0042733 | embryonic digit morphogenesis |
| Biological Process | GO:0035050 | embryonic heart tube development |
| Biological Process | GO:0003347 | epicardial cell to mesenchymal cell transition |
| Biological Process | GO:0002070 | epithelial cell maturation |
| Biological Process | GO:0090162 | establishment of epithelial cell polarity |
| Biological Process | GO:0000132 | establishment of mitotic spindle orientation |
| Biological Process | GO:0140115 | export across plasma membrane |
| Biological Process | GO:0014047 | glutamate secretion |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0001947 | heart looping |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0002088 | lens development in camera-type eye |
| Biological Process | GO:0035437 | maintenance of protein localization in endoplasmic reticulum |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0099111 | microtubule-based transport |
| Biological Process | GO:0060156 | milk ejection reflex |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:2000279 | negative regulation of DNA biosynthetic process |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0032277 | negative regulation of gonadotropin secretion |
| Biological Process | GO:1901164 | negative regulation of trophoblast cell migration |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:2000987 | positive regulation of behavioral fear response |
| Biological Process | GO:0010652 | positive regulation of cell communication by chemical coupling |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| Biological Process | GO:1904446 | positive regulation of establishment of Sertoli cell barrier |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0003104 | positive regulation of glomerular filtration |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0045836 | positive regulation of meiotic nuclear division |
| Biological Process | GO:1905772 | positive regulation of mesodermal cell differentiation |
| Biological Process | GO:1905332 | positive regulation of morphogenesis of an epithelium |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:2000648 | positive regulation of stem cell proliferation |
| Biological Process | GO:0045844 | positive regulation of striated muscle tissue development |
| Biological Process | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0045907 | positive regulation of vasoconstriction |
| Biological Process | GO:0110053 | regulation of actin filament organization |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization |
| Biological Process | GO:2000810 | regulation of bicellular tight junction assembly |
| Biological Process | GO:0060312 | regulation of blood vessel remodeling |
| Biological Process | GO:0030500 | regulation of bone mineralization |
| Biological Process | GO:0046850 | regulation of bone remodeling |
| Biological Process | GO:0051924 | regulation of calcium ion transport |
| Biological Process | GO:0010649 | regulation of cell communication by electrical coupling |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.