Overview
| Uniprot ID | P23258 |
|---|
| Protein Name | Tubulin gamma-1 chain |
|---|
| Gene Name | TUBG1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 287 |
QSVASVRKTTVLDVM |
Function
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). Plays a role in sperm morphological development during late stage spermiogenesis, particularly the anchoring of the sperm head to the tail (PubMed:38870534)
Protein Sequence
10
MPREIITLQL
20
GQCGNQIGFE
30
FWKQLCAEHG
40
ISPEGIVEEF
50
ATEGTDRKDV
60
FFYQADDEHY
70
IPRAVLLDLE
80
PRVIHSILNS
90
PYAKLYNPEN
100
IYLSEHGGGA
110
GNNWASGFSQ
120
GEKIHEDIFD
130
IIDREADGSD
140
SLEGFVLCHS
150
IAGGTGSGLG
160
SYLLERLNDR
170
YPKKLVQTYS
180
VFPNQDEMSD
190
VVVQPYNSLL
200
TLKRLTQNAD
210
CVVVLDNTAL
220
NRIATDRLHI
230
QNPSFSQINQ
240
LVSTIMSAST
250
TTLRYPGYMN
260
NDLIGLIASL
270
IPTPRLHFLM
280
TGYTPLTTDQ
290
SVASVRKTTV
300
LDVMRRLLQP
310
KNVMVSTGRD
320
RQTNHCYIAI
330
LNIIQGEVDP
340
TQVHKSLQRI
350
RERKLANFIP
360
WGPASIQVAL
370
SRKSPYLPSA
380
HRVSGLMMAN
390
HTSISSLFER
400
TCRQYDKLRK
410
REAFLEQFRK
420
EDMFKDNFDE
430
MDTSREIVQQ
440
LIDEYHAATR
450
PDYISWGTQE
Q
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0045177 |
apical part of cell |
| Cellular Component |
GO:0031252 |
cell leading edge |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0000794 |
condensed nuclear chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005881 |
cytoplasmic microtubule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000930 |
gamma-tubulin complex |
| Cellular Component |
GO:0000931 |
gamma-tubulin ring complex |
| Cellular Component |
GO:1990498 |
mitotic spindle microtubule |
| Cellular Component |
GO:0097730 |
non-motile cilium |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000242 |
pericentriolar material |
| Cellular Component |
GO:0005827 |
polar microtubule |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0005819 |
spindle |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0140490 |
microtubule nucleator activity |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0031122 |
cytoplasmic microtubule organization |
| Biological Process |
GO:0000212 |
meiotic spindle organization |
| Biological Process |
GO:0000226 |
microtubule cytoskeleton organization |
| Biological Process |
GO:0007020 |
microtubule nucleation |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0000070 |
mitotic sister chromatid segregation |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.