Search Results
Overview
| Uniprot ID | P23368 |
|---|---|
| Protein Name | NAD-dependent malic enzyme, mitochondrial |
| Gene Name | ME2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 74 | RFHRNLKKMTSPLEK |
Function
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate
Protein Sequence
10
MLSRLRVVST
20
TCTLACRHLH
30
IKEKGKPLML
40
NPRTNKGMAF
50
TLQERQMLGL
60
QGLLPPKIET
70
QDIQALRFHR
80
NLKKMTSPLE
90
KYIYIMGIQE
100
RNEKLFYRIL
110
QDDIESLMPI
120
VYTPTVGLAC
130
SQYGHIFRRP
140
KGLFISISDR
150
GHVRSIVDNW
160
PENHVKAVVV
170
TDGERILGLG
180
DLGVYGMGIP
190
VGKLCLYTAC
200
AGIRPDRCLP
210
VCIDVGTDNI
220
ALLKDPFYMG
230
LYQKRDRTQQ
240
YDDLIDEFMK
250
AITDRYGRNT
260
LIQFEDFGNH
270
NAFRFLRKYR
280
EKYCTFNDDI
290
QGTAAVALAG
300
LLAAQKVISK
310
PISEHKILFL
320
GAGEAALGIA
330
NLIVMSMVEN
340
GLSEQEAQKK
350
IWMFDKYGLL
360
VKGRKAKIDS
370
YQEPFTHSAP
380
ESIPDTFEDA
390
VNILKPSTII
400
GVAGAGRLFT
410
PDVIRAMASI
420
NERPVIFALS
430
NPTAQAECTA
440
EEAYTLTEGR
450
CLFASGSPFG
460
PVKLTDGRVF
470
TPGQGNNVYI
480
FPGVALAVIL
490
CNTRHISDSV
500
FLEAAKALTS
510
QLTDEELAQG
520
RLYPPLANIQ
530
EVSINIAIKV
540
TEYLYANKMA
550
FRYPEPEDKA
560
KYVKERTWRS
570
EYDSLLPDVY
580
EWPESASSPP
VITE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0004471 | malate dehydrogenase (decarboxylating) (NAD+) activity |
| Molecular Function | GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity |
| Molecular Function | GO:0004470 | malic enzyme activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0008948 | oxaloacetate decarboxylase activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:1902031 | regulation of NADP metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.