Search Results

Overview

Uniprot IDP23378
Protein NameGlycine dehydrogenase (decarboxylating), mitochondrial
Gene NameGLDC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 IRLKRPLKMEDPVCE
238 AVVQTRAKYTGVLTE
358 VTRDATGKEVYRLAL
376 EQHIRRDKATSNICT
423 LILSEGLKRAGHQLQ
447 IQCGCSVKEVLGRAA
636 IRAYLNQKGEGHRTV
648 RTVCLIPKSAHGTNP
664 SAHMAGMKIQPVEVD
672 IQPVEVDKYGNIDAV
73 RHIGPGDKDQREMLQ
773 GMGPIGVKKHLAPFL
774 MGPIGVKKHLAPFLP
789 NHPVISLKRNEDACP
872 LDTRPFKKSANIEAV
883 IEAVDVAKRLQDYGF

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH)

Protein Sequence

10 MQSCARAWGL 20 RLGRGVGGGR 30 RLAGGSGPCW 40 APRSRDSSSG 50 GGDSAAAGAS 60 RLLERLLPRH 70 DDFARRHIGP 80 GDKDQREMLQ 90 TLGLASIDEL 100 IEKTVPANIR 110 LKRPLKMEDP 120 VCENEILATL 130 HAISSKNQIW 140 RSYIGMGYYN 150 CSVPQTILRN 160 LLENSGWITQ 170 YTPYQPEVSQ 180 GRLESLLNYQ 190 TMVCDITGLD 200 MANASLLDEG 210 TAAAEALQLC 220 YRHNKRRKFL 230 VDPRCHPQTI 240 AVVQTRAKYT 250 GVLTELKLPC 260 EMDFSGKDVS 270 GVLFQYPDTE 280 GKVEDFTELV 290 ERAHQSGSLA 300 CCATDLLALC 310 ILRPPGEFGV 320 DIALGSSQRF 330 GVPLGYGGPH 340 AAFFAVRESL 350 VRMMPGRMVG 360 VTRDATGKEV 370 YRLALQTREQ 380 HIRRDKATSN 390 ICTAQALLAN 400 MAAMFAIYHG 410 SHGLEHIARR 420 VHNATLILSE 430 GLKRAGHQLQ 440 HDLFFDTLKI 450 QCGCSVKEVL 460 GRAAQRQINF 470 RLFEDGTLGI 480 SLDETVNEKD 490 LDDLLWIFGC 500 ESSAELVAES 510 MGEECRGIPG 520 SVFKRTSPFL 530 THQVFNSYHS 540 ETNIVRYMKK 550 LENKDISLVH 560 SMIPLGSCTM 570 KLNSSSELAP 580 ITWKEFANIH 590 PFVPLDQAQG 600 YQQLFRELEK 610 DLCELTGYDQ 620 VCFQPNSGAQ 630 GEYAGLATIR 640 AYLNQKGEGH 650 RTVCLIPKSA 660 HGTNPASAHM 670 AGMKIQPVEV 680 DKYGNIDAVH 690 LKAMVDKHKE 700 NLAAIMITYP 710 STNGVFEENI 720 SDVCDLIHQH 730 GGQVYLDGAN 740 MNAQVGICRP 750 GDFGSDVSHL 760 NLHKTFCIPH 770 GGGGPGMGPI 780 GVKKHLAPFL 790 PNHPVISLKR 800 NEDACPVGTV 810 SAAPWGSSSI 820 LPISWAYIKM 830 MGGKGLKQAT 840 ETAILNANYM 850 AKRLETHYRI 860 LFRGARGYVG 870 HEFILDTRPF 880 KKSANIEAVD 890 VAKRLQDYGF 900 HAPTMSWPVA 910 GTLMVEPTES 920 EDKAELDRFC 930 DAMISIRQEI 940 ADIEEGRIDP 950 RVNPLKMSPH 960 SLTCVTSSHW 970 DRPYSREVAA 980 FPLPFVKPEN 990 KFWPTIARID 1000 DIYGDQHLVC 1010 TCPPMEVYES 1020 PFSEQKRASS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005960 glycine cleavage complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0016594 glycine binding
Molecular Function GO:0004375 glycine dehydrogenase (decarboxylating) activity
Molecular Function GO:0016829 lyase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0070280 pyridoxal binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0006546 glycine catabolic process
Biological Process GO:0019464 glycine decarboxylation via glycine cleavage system
Biological Process GO:1903442 response to lipoic acid
Biological Process GO:0036255 response to methylamine

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.