Search Results
Overview
| Uniprot ID | P23381 |
|---|---|
| Protein Name | Tryptophan--tRNA ligase, cytoplasmic |
| Gene Name | WARS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | FGSSKIDKELINRIE |
| 256 | KNVVKIQKHVTFNQV |
| 366 | IFLTDTAKQIKTKVN |
| 431 | AMLTGELKKALIEVL |
Function
Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp)
Protein Sequence
10
MPNSEPASLL
20
ELFNSIATQG
30
ELVRSLKAGN
40
ASKDEIDSAV
50
KMLVSLKMSY
60
KAAAGEDYKA
70
DCPPGNPAPT
80
SNHGPDATEA
90
EEDFVDPWTV
100
QTSSAKGIDY
110
DKLIVRFGSS
120
KIDKELINRI
130
ERATGQRPHH
140
FLRRGIFFSH
150
RDMNQVLDAY
160
ENKKPFYLYT
170
GRGPSSEAMH
180
VGHLIPFIFT
190
KWLQDVFNVP
200
LVIQMTDDEK
210
YLWKDLTLDQ
220
AYSYAVENAK
230
DIIACGFDIN
240
KTFIFSDLDY
250
MGMSSGFYKN
260
VVKIQKHVTF
270
NQVKGIFGFT
280
DSDCIGKISF
290
PAIQAAPSFS
300
NSFPQIFRDR
310
TDIQCLIPCA
320
IDQDPYFRMT
330
RDVAPRIGYP
340
KPALLHSTFF
350
PALQGAQTKM
360
SASDPNSSIF
370
LTDTAKQIKT
380
KVNKHAFSGG
390
RDTIEEHRQF
400
GGNCDVDVSF
410
MYLTFFLEDD
420
DKLEQIRKDY
430
TSGAMLTGEL
440
KKALIEVLQP
450
LIAEHQARRK
460
EVTDEIVKEF
470
MTPRKLSFDF
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0004830 | tryptophan-tRNA ligase activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045765 | regulation of angiogenesis |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0006436 | tryptophanyl-tRNA aminoacylation |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.