Overview
| Uniprot ID | P23458 |
|---|
| Protein Name | Tyrosine-protein kinase JAK1 |
|---|
| Gene Name | JAK1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 860 |
PDIVSEKKPATEVDP |
Function
Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA (PubMed:11909529, PubMed:12133952, PubMed:15194700, PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552, PubMed:9188471). Functionnally, is involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Mechanistically, in response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). Involved in the MT-RNR2/humanin-mediated signaling pathway leading to STAT3 phosphorylation (PubMed:27384491). Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3 (PubMed:11294841). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). Involved in the Interleukin-31-mediated signaling pathway through the IL31 receptor complex (heterodimers composed of OSMR and IL31RA) (PubMed:15194700)
Protein Sequence
10
MQYLNIKEDC
20
NAMAFCAKMR
30
SSKKTEVNLE
40
APEPGVEVIF
50
YLSDREPLRL
60
GSGEYTAEEL
70
CIRAAQACRI
80
SPLCHNLFAL
90
YDENTKLWYA
100
PNRTITVDDK
110
MSLRLHYRMR
120
FYFTNWHGTN
130
DNEQSVWRHS
140
PKKQKNGYEK
150
KKIPDATPLL
160
DASSLEYLFA
170
QGQYDLVKCL
180
APIRDPKTEQ
190
DGHDIENECL
200
GMAVLAISHY
210
AMMKKMQLPE
220
LPKDISYKRY
230
IPETLNKSIR
240
QRNLLTRMRI
250
NNVFKDFLKE
260
FNNKTICDSS
270
VSTHDLKVKY
280
LATLETLTKH
290
YGAEIFETSM
300
LLISSENEMN
310
WFHSNDGGNV
320
LYYEVMVTGN
330
LGIQWRHKPN
340
VVSVEKEKNK
350
LKRKKLENKH
360
KKDEEKNKIR
370
EEWNNFSYFP
380
EITHIVIKES
390
VVSINKQDNK
400
KMELKLSSHE
410
EALSFVSLVD
420
GYFRLTADAH
430
HYLCTDVAPP
440
LIVHNIQNGC
450
HGPICTEYAI
460
NKLRQEGSEE
470
GMYVLRWSCT
480
DFDNILMTVT
490
CFEKSEQVQG
500
AQKQFKNFQI
510
EVQKGRYSLH
520
GSDRSFPSLG
530
DLMSHLKKQI
540
LRTDNISFML
550
KRCCQPKPRE
560
ISNLLVATKK
570
AQEWQPVYPM
580
SQLSFDRILK
590
KDLVQGEHLG
600
RGTRTHIYSG
610
TLMDYKDDEG
620
TSEEKKIKVI
630
LKVLDPSHRD
640
ISLAFFEAAS
650
MMRQVSHKHI
660
VYLYGVCVRD
670
VENIMVEEFV
680
EGGPLDLFMH
690
RKSDVLTTPW
700
KFKVAKQLAS
710
ALSYLEDKDL
720
VHGNVCTKNL
730
LLAREGIDSE
740
CGPFIKLSDP
750
GIPITVLSRQ
760
ECIERIPWIA
770
PECVEDSKNL
780
SVAADKWSFG
790
TTLWEICYNG
800
EIPLKDKTLI
810
EKERFYESRC
820
RPVTPSCKEL
830
ADLMTRCMNY
840
DPNQRPFFRA
850
IMRDINKLEE
860
QNPDIVSEKK
870
PATEVDPTHF
880
EKRFLKRIRD
890
LGEGHFGKVE
900
LCRYDPEGDN
910
TGEQVAVKSL
920
KPESGGNHIA
930
DLKKEIEILR
940
NLYHENIVKY
950
KGICTEDGGN
960
GIKLIMEFLP
970
SGSLKEYLPK
980
NKNKINLKQQ
990
LKYAVQICKG
1000
MDYLGSRQYV
1010
HRDLAARNVL
1020
VESEHQVKIG
1030
DFGLTKAIET
1040
DKEYYTVKDD
1050
RDSPVFWYAP
1060
ECLMQSKFYI
1070
ASDVWSFGVT
1080
LHELLTYCDS
1090
DSSPMALFLK
1100
MIGPTHGQMT
1110
VTRLVNTLKE
1120
GKRLPCPPNC
1130
PDEVYQLMRK
1140
CWEFQPSNRT
1150
SFQNLIEGFE
ALLK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0009898 |
cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0031730 |
CCR5 chemokine receptor binding |
| Molecular Function |
GO:0005131 |
growth hormone receptor binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Molecular Function |
GO:0004713 |
protein tyrosine kinase activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0007259 |
cell surface receptor signaling pathway via JAK-STAT |
| Biological Process |
GO:0019221 |
cytokine-mediated signaling pathway |
| Biological Process |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
| Biological Process |
GO:0140105 |
interleukin-10-mediated signaling pathway |
| Biological Process |
GO:0038154 |
interleukin-11-mediated signaling pathway |
| Biological Process |
GO:0035723 |
interleukin-15-mediated signaling pathway |
| Biological Process |
GO:0038110 |
interleukin-2-mediated signaling pathway |
| Biological Process |
GO:0035771 |
interleukin-4-mediated signaling pathway |
| Biological Process |
GO:0038043 |
interleukin-5-mediated signaling pathway |
| Biological Process |
GO:0070102 |
interleukin-6-mediated signaling pathway |
| Biological Process |
GO:0038111 |
interleukin-7-mediated signaling pathway |
| Biological Process |
GO:0038113 |
interleukin-9-mediated signaling pathway |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0034112 |
positive regulation of homotypic cell-cell adhesion |
| Biological Process |
GO:1900182 |
positive regulation of protein localization to nucleus |
| Biological Process |
GO:1903672 |
positive regulation of sprouting angiogenesis |
| Biological Process |
GO:0150105 |
protein localization to cell-cell junction |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0046677 |
response to antibiotic |
| Biological Process |
GO:0072540 |
T-helper 17 cell lineage commitment |
| Biological Process |
GO:0060337 |
type I interferon-mediated signaling pathway |
| Biological Process |
GO:0060333 |
type II interferon-mediated signaling pathway |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.