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Overview

Uniprot IDP23497
Protein NameNuclear autoantigen Sp-100
Gene NameSP100
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
300 LVDIKKEKPFSNSKV
306 EKPFSNSKVECQAQA
733 IFAKEKGKFEDMAKA
742 EDMAKADKAHYEREM
762 PKGEKKKKFKDPNAP
764 GEKKKKFKDPNAPKR

Function

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation

Protein Sequence

10 MAGGGGDLST 20 RRLNECISPV 30 ANEMNHLPAH 40 SHDLQRMFTE 50 DQGVDDRLLY 60 DIVFKHFKRN 70 KVEISNAIKK 80 TFPFLEGLRD 90 RDLITNKMFE 100 DSQDSCRNLV 110 PVQRVVYNVL 120 SELEKTFNLP 130 VLEALFSDVN 140 MQEYPDLIHI 150 YKGFENVIHD 160 KLPLQESEEE 170 EREERSGLQL 180 SLEQGTGENS 190 FRSLTWPPSG 200 SPSHAGTTPP 210 ENGLSEHPCE 220 TEQINAKRKD 230 TTSDKDDSLG 240 SQQTNEQCAQ 250 KAEPTESCEQ 260 IAVQVNNGDA 270 GREMPCPLPC 280 DEESPEAELH 290 NHGIQINSCS 300 VRLVDIKKEK 310 PFSNSKVECQ 320 AQARTHHNQA 330 SDIIVISSED 340 SEGSTDVDEP 350 LEVFISAPRS 360 EPVINNDNPL 370 ESNDEKEGQE 380 ATCSRPQIVP 390 EPMDFRKLST 400 FRESFKKRVI 410 GQDHDFSESS 420 EEEAPAEASS 430 GALRSKHGEK 440 APMTSRSTST 450 WRIPSRKRRF 460 SSSDFSDLSN 470 GEELQETCSS 480 SLRRGSGSQP 490 QEPENKKCSC 500 VMCFPKGVPR 510 SQEARTESSQ 520 ASDMMDTMDV 530 ENNSTLEKHS 540 GKRRKKRRHR 550 SKVNGLQRGR 560 KKDRPRKHLT 570 LNNKVQKKRW 580 QQRGRKANTR 590 PLKRRRKRGP 600 RIPKDENINF 610 KQSELPVTCG 620 EVKGTLYKER 630 FKQGTSKKCI 640 QSEDKKWFTP 650 REFEIEGDRG 660 ASKNWKLSIR 670 CGGYTLKVLM 680 ENKFLPEPPS 690 TRKKRILESH 700 NNTLVDPCEE 710 HKKKNPDASV 720 KFSEFLKKCS 730 ETWKTIFAKE 740 KGKFEDMAKA 750 DKAHYEREMK 760 TYIPPKGEKK 770 KKFKDPNAPK 780 RPPLAFFLFC 790 SEYRPKIKGE 800 HPGLSIDDVV 810 KKLAGMWNNT 820 AAADKQFYEK 830 KAAKLKEKYK 840 KDIAAYRAKG 850 KPNSAKKRVV 860 KAEKSKKKKE 870 EEEDEEDEQE EENEEDDDK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000781 chromosome, telomeric region
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0050792 regulation of viral process
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0034340 response to type I interferon
Biological Process GO:0034341 response to type II interferon
Biological Process GO:0048384 retinoic acid receptor signaling pathway
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0060337 type I interferon-mediated signaling pathway
Biological Process GO:0060333 type II interferon-mediated signaling pathway
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0030330 DNA damage response, signal transduction by p53 class mediator
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045185 maintenance of protein location
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010596 negative regulation of endothelial cell migration
Biological Process GO:0046826 negative regulation of protein export from nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032897 negative regulation of viral transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:1902044 regulation of Fas signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.