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Overview

Uniprot IDP23511
Protein NameNuclear transcription factor Y subunit alpha
Gene NameNFYA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
284 KRRQARAKLEAEGKI
290 AKLEAEGKIPKERRK

Function

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1

Protein Sequence

10 MEQYTANSNS 20 STEQIVVQAG 30 QIQQQQQGGV 40 TAVQLQTEAQ 50 VASASGQQVQ 60 TLQVVQGQPL 70 MVQVSGGQLI 80 TSTGQPIMVQ 90 AVPGGQGQTI 100 MQVPVSGTQG 110 LQQIQLVPPG 120 QIQIQGGQAV 130 QVQGQQGQTQ 140 QIIIQQPQTA 150 VTAGQTQTQQ 160 QIAVQGQQVA 170 QTAEGQTIVY 180 QPVNADGTIL 190 QQVTVPVSGM 200 ITIPAASLAG 210 AQIVQTGANT 220 NTTSSGQGTV 230 TVTLPVAGNV 240 VNSGGMVMMV 250 PGAGSVPAIQ 260 RIPLPGAEML 270 EEEPLYVNAK 280 QYHRILKRRQ 290 ARAKLEAEGK 300 IPKERRKYLH 310 ESRHRHAMAR 320 KRGEGGRFFS 330 PKEKDSPHMQ 340 DPNQADEEAM TQIIRVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016602 CCAAT-binding factor complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032993 protein-DNA complex
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0048511 rhythmic process
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.