Search Results

Overview

Uniprot ID	P23526
Protein Name	Adenosylhomocysteinase
Gene Name	AHCY
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
186	NVNDSVTKSKFDNLY
188	NDSVTKSKFDNLYGC
20	GLAAWGRKALDIAEN
226	AGYGDVGKGCAQALR
322	AVEKVNIKPQVDRYR
388	VGVHFLPKKLDEAVA
389	GVHFLPKKLDEAVAE
401	VAEAHLGKLNVKLTK
405	HLGKLNVKLTKLTEK

Function

Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity)

Protein Sequence

10 MSDKLPYKVA 20 DIGLAAWGRK 30 ALDIAENEMP 40 GLMRMRERYS 50 ASKPLKGARI 60 AGCLHMTVET 70 AVLIETLVTL 80 GAEVQWSSCN 90 IFSTQDHAAA 100 AIAKAGIPVY 110 AWKGETDEEY 120 LWCIEQTLYF 130 KDGPLNMILD 140 DGGDLTNLIH 150 TKYPQLLPGI 160 RGISEETTTG 170 VHNLYKMMAN 180 GILKVPAINV 190 NDSVTKSKFD 200 NLYGCRESLI 210 DGIKRATDVM 220 IAGKVAVVAG 230 YGDVGKGCAQ 240 ALRGFGARVI 250 ITEIDPINAL 260 QAAMEGYEVT 270 TMDEACQEGN 280 IFVTTTGCID 290 IILGRHFEQM 300 KDDAIVCNIG 310 HFDVEIDVKW 320 LNENAVEKVN 330 IKPQVDRYRL 340 KNGRRIILLA 350 EGRLVNLGCA 360 MGHPSFVMSN 370 SFTNQVMAQI 380 ELWTHPDKYP 390 VGVHFLPKKL 400 DEAVAEAHLG 410 KLNVKLTKLT 420 EKQAQYLGMS 430 CDGPFKPDHY RY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0004013	adenosylhomocysteinase activity
Biological Process	GO:0006730	one-carbon metabolic process
Biological Process	GO:0033353	S-adenosylmethionine cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.