Search Results
Overview
| Uniprot ID | P23528 |
|---|---|
| Protein Name | Cofilin-1 |
| Gene Name | CFL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | ESAPLKSKMIYASSK |
| 121 | KMIYASSKDAIKKKL |
| 13 | AVSDGVIKVFNDMKV |
| 132 | KKKLTGIKHELQANC |
| 144 | ANCYEEVKDRCTLAE |
| 19 | IKVFNDMKVRKSSTP |
| 22 | FNDMKVRKSSTPEEV |
| 30 | SSTPEEVKKRKKAVL |
| 31 | STPEEVKKRKKAVLF |
| 34 | EEVKKRKKAVLFCLS |
| 44 | LFCLSEDKKNIILEE |
| 45 | FCLSEDKKNIILEEG |
| 53 | NIILEEGKEILVGDV |
| 73 | DPYATFVKMLPDKDC |
| 78 | FVKMLPDKDCRYALY |
| 92 | YDATYETKESKKEDL |
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157, PubMed:33670794). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0090732 | cofilin-actin rod |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0031258 | lamellipodium membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:1902936 | phosphatidylinositol bisphosphate binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071362 | cellular response to ether |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0051293 | establishment of spindle localization |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0032232 | negative regulation of actin filament bundle assembly |
| Biological Process | GO:0030835 | negative regulation of actin filament depolymerization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0007162 | negative regulation of cell adhesion |
| Biological Process | GO:2000146 | negative regulation of cell motility |
| Biological Process | GO:1902951 | negative regulation of dendritic spine maintenance |
| Biological Process | GO:0010593 | negative regulation of lamellipodium assembly |
| Biological Process | GO:1905875 | negative regulation of postsynaptic density organization |
| Biological Process | GO:0051511 | negative regulation of unidimensional cell growth |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:2000814 | positive regulation of barbed-end actin filament capping |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:2000147 | positive regulation of cell motility |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:0040019 | positive regulation of embryonic development |
| Biological Process | GO:2000784 | positive regulation of establishment of cell polarity regulating cell shape |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:1905873 | positive regulation of protein localization to cell leading edge |
| Biological Process | GO:0045862 | positive regulation of proteolysis |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0061001 | regulation of dendritic spine morphogenesis |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0007266 | Rho protein signal transduction |
Reference
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[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
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