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Overview

Uniprot IDP23565
Protein NameAlpha-internexin
Gene NameIna
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
17 CSASSYRKVFGDGSR
197 EGAERALKAQQRDVD
216 ARLDLEKKVESLLDE
288 QSAEEWYKSKFANLN
290 AEEWYKSKFANLNEQ
369 ESDLRNTKSEMARHL
398 IEIAAYRKLLEGEET
438 ILSSTTSKVSSAGLS
447 SSAGLSLKKEEEEEE
448 SAGLSLKKEEEEEEE
462 EEEEGASKEVTKKTS
488 ETVVSTKKTEKSTIE
491 VSTKKTEKSTIEEIT
504 ITTSSSQKM******
88 AARTNEYKIIRTNEK
95 KIIRTNEKEQLQGLN

Function

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity)

Protein Sequence

10 MSFGSEHYLC 20 SASSYRKVFG 30 DGSRLSARLS 40 GPGASGSFRS 50 QSLSRSNVAS 60 TAACSSASSL 70 GLGLAYRRLP 80 ASDGLDLSQA 90 AARTNEYKII 100 RTNEKEQLQG 110 LNDRFAVFIE 120 KVHQLETQNR 130 ALEAELAALR 140 QRHAEPSRVG 150 ELFQRELREL 160 RAQLEEASSA 170 RAQALLERDG 180 LAEEVQRLRA 190 RCEEESRGRE 200 GAERALKAQQ 210 RDVDGATLAR 220 LDLEKKVESL 230 LDELAFVRQV 240 HDEEVAELLA 250 TLQASSQAAA 260 EVDVAVAKPD 270 LTSALREIRA 280 QYESLAAKNL 290 QSAEEWYKSK 300 FANLNEQAAR 310 STEAIRASRE 320 EIHEYRRQLQ 330 ARTIEIEGLR 340 GANESLERQI 350 LELEERHSAE 360 VAGYQDSIGQ 370 LESDLRNTKS 380 EMARHLREYQ 390 DLLNVKMALD 400 IEIAAYRKLL 410 EGEETRFSTS 420 GLSISGLNPL 430 PNPSYLLPPR 440 ILSSTTSKVS 450 SAGLSLKKEE 460 EEEEEEEEGA 470 SKEVTKKTSK 480 VGESFEETLE 490 ETVVSTKKTE 500 KSTIEEITTS SSQKM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0099092 postsynaptic density, intracellular component
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0005883 neurofilament
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0099160 postsynaptic intermediate filament cytoskeleton
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process GO:0030154 cell differentiation
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0007399 nervous system development
Biological Process GO:0060052 neurofilament cytoskeleton organization
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:0042246 tissue regeneration

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.