Search Results
Overview
| Uniprot ID | P23634 |
|---|---|
| Protein Name | Plasma membrane calcium-transporting ATPase 4 |
| Gene Name | ATP2B4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1058 | TRSLKFLKEAGHGTT |
Function
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)
Protein Sequence
10
MTNPSDRVLP
20
ANSMAESREG
30
DFGCTVMELR
40
KLMELRSRDA
50
LTQINVHYGG
60
VQNLCSRLKT
70
SPVEGLSGNP
80
ADLEKRRQVF
90
GHNVIPPKKP
100
KTFLELVWEA
110
LQDVTLIILE
120
IAAIISLVLS
130
FYRPAGEENE
140
LCGQVATTPE
150
DENEAQAGWI
160
EGAAILFSVI
170
IVVLVTAFND
180
WSKEKQFRGL
190
QCRIEQEQKF
200
SIIRNGQLIQ
210
LPVAEIVVGD
220
IAQVKYGDLL
230
PADGILIQGN
240
DLKIDESSLT
250
GESDHVKKSL
260
DKDPMLLSGT
270
HVMEGSGRMV
280
VTAVGVNSQT
290
GIILTLLGVN
300
EDDEGEKKKK
310
GKKQGVPENR
320
NKAKTQDGVA
330
LEIQPLNSQE
340
GIDNEEKDKK
350
AVKVPKKEKS
360
VLQGKLTRLA
370
VQIGKAGLLM
380
SALTVFILIL
390
YFVIDNFVIN
400
RRPWLPECTP
410
IYIQYFVKFF
420
IIGITVLVVA
430
VPEGLPLAVT
440
ISLAYSVKKM
450
MKDNNLVRHL
460
DACETMGNAT
470
AICSDKTGTL
480
TMNRMTVVQA
490
YIGGIHYRQI
500
PSPDVFLPKV
510
LDLIVNGISI
520
NSAYTSKILP
530
PEKEGGLPRQ
540
VGNKTECALL
550
GFVTDLKQDY
560
QAVRNEVPEE
570
KLYKVYTFNS
580
VRKSMSTVIR
590
NPNGGFRMYS
600
KGASEIILRK
610
CNRILDRKGE
620
AVPFKNKDRD
630
DMVRTVIEPM
640
ACDGLRTICI
650
AYRDFDDTEP
660
SWDNENEILT
670
ELTCIAVVGI
680
EDPVRPEVPD
690
AIAKCKQAGI
700
TVRMVTGDNI
710
NTARAIATKC
720
GILTPGDDFL
730
CLEGKEFNRL
740
IRNEKGEVEQ
750
EKLDKIWPKL
760
RVLARSSPTD
770
KHTLVKGIID
780
STVGEHRQVV
790
AVTGDGTNDG
800
PALKKADVGF
810
AMGIAGTDVA
820
KEASDIILTD
830
DNFTSIVKAV
840
MWGRNVYDSI
850
SKFLQFQLTV
860
NVVAVIVAFT
870
GACITQDSPL
880
KAVQMLWVNL
890
IMDTFASLAL
900
ATEPPTESLL
910
KRRPYGRNKP
920
LISRTMMKNI
930
LGHAFYQLIV
940
IFILVFAGEK
950
FFDIDSGRKA
960
PLHSPPSQHY
970
TIVFNTFVLM
980
QLFNEINSRK
990
IHGEKNVFSG
1000
IYRNIIFCSV
1010
VLGTFICQIF
1020
IVEFGGKPFS
1030
CTSLSLSQWL
1040
WCLFIGIGEL
1050
LWGQFISAIP
1060
TRSLKFLKEA
1070
GHGTTKEEIT
1080
KDAEGLDEID
1090
HAEMELRRGQ
1100
ILWFRGLNRI
1110
QTQIDVINTF
1120
QTGASFKGVL
1130
RRQNMGQHLD
1140
VKLVPSSSYI
1150
KVVKAFHSSL
1160
HESIQKPYNQ
1170
KSIHSFMTHP
1180
EFAIEEELPR
1190
TPLLDEEEEE
1200
NPDKASKFGT
1210
RVLLLDGEVT
1220
PYANTNNNAV
1230
DCNQVQLPQS
1240
DSSLQSLETS
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Biological Process | GO:0014832 | urinary bladder smooth muscle contraction |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097228 | sperm principal piece |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0015085 | calcium ion transmembrane transporter activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0036487 | nitric-oxide synthase inhibitor activity |
| Molecular Function | GO:0005388 | P-type calcium transporter activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030346 | protein phosphatase 2B binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Biological Process | GO:1901660 | calcium ion export |
| Biological Process | GO:0098703 | calcium ion import across plasma membrane |
| Biological Process | GO:0097553 | calcium ion transmembrane import into cytosol |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:1905145 | cellular response to acetylcholine |
| Biological Process | GO:0071872 | cellular response to epinephrine stimulus |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0071878 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:1900082 | negative regulation of arginine catabolic process |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| Biological Process | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:1903249 | negative regulation of citrulline biosynthetic process |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0098736 | negative regulation of the force of heart contraction |
| Biological Process | GO:0003407 | neural retina development |
| Biological Process | GO:0038060 | nitric oxide-cGMP-mediated signaling |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:1903779 | regulation of cardiac conduction |
| Biological Process | GO:1902806 | regulation of cell cycle G1/S phase transition |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:1902305 | regulation of sodium ion transmembrane transport |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051599 | response to hydrostatic pressure |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.