Search Results
Overview
| Uniprot ID | P23786 |
|---|---|
| Protein Name | Carnitine O-palmitoyltransferase 2, mitochondrial |
| Gene Name | CPT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | EQLVALDKQNKHTSY |
| 189 | KSDTITFKRLIRFVP |
| 239 | DELFTDDKARHLLVL |
| 305 | IWAELRQKLMSSGNE |
| 537 | QMMVECSKYHGQLTK |
| 544 | KYHGQLTKEAAMGQG |
| 69 | RRYLSAQKPLLNDGQ |
| 79 | LNDGQFRKTEQFCKS |
Function
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056)
Protein Sequence
10
MVPRLLLRAW
20
PRGPAVGPGA
30
PSRPLSAGSG
40
PGQYLQRSIV
50
PTMHYQDSLP
60
RLPIPKLEDT
70
IRRYLSAQKP
80
LLNDGQFRKT
90
EQFCKSFENG
100
IGKELHEQLV
110
ALDKQNKHTS
120
YISGPWFDMY
130
LSARDSVVLN
140
FNPFMAFNPD
150
PKSEYNDQLT
160
RATNMTVSAI
170
RFLKTLRAGL
180
LEPEVFHLNP
190
AKSDTITFKR
200
LIRFVPSSLS
210
WYGAYLVNAY
220
PLDMSQYFRL
230
FNSTRLPKPS
240
RDELFTDDKA
250
RHLLVLRKGN
260
FYIFDVLDQD
270
GNIVSPSEIQ
280
AHLKYILSDS
290
SPAPEFPLAY
300
LTSENRDIWA
310
ELRQKLMSSG
320
NEESLRKVDS
330
AVFCLCLDDF
340
PIKDLVHLSH
350
NMLHGDGTNR
360
WFDKSFNLII
370
AKDGSTAVHF
380
EHSWGDGVAV
390
LRFFNEVFKD
400
STQTPAVTPQ
410
SQPATTDSTV
420
TVQKLNFELT
430
DALKTGITAA
440
KEKFDATMKT
450
LTIDCVQFQR
460
GGKEFLKKQK
470
LSPDAVAQLA
480
FQMAFLRQYG
490
QTVATYESCS
500
TAAFKHGRTE
510
TIRPASVYTK
520
RCSEAFVREP
530
SRHSAGELQQ
540
MMVECSKYHG
550
QLTKEAAMGQ
560
GFDRHLFALR
570
HLAAAKGIIL
580
PELYLDPAYG
590
QINHNVLSTS
600
TLSSPAVNLG
610
GFAPVVSDGF
620
GVGYAVHDNW
630
IGCNVSSYPG
640
RNAREFLQCV
650
EKALEDMFDA
LEGKSIKS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0016746 | acyltransferase activity |
| Molecular Function | GO:0008458 | carnitine O-octanoyltransferase activity |
| Molecular Function | GO:0004095 | carnitine O-palmitoyltransferase activity |
| Biological Process | GO:0009437 | carnitine metabolic process |
| Biological Process | GO:0006853 | carnitine shuttle |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.