Search Results
Overview
| Uniprot ID | P23919 |
|---|---|
| Protein Name | Thymidylate kinase |
| Gene Name | DTYMK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | GKSTQSRKLVEALCA |
| 59 | LLSSYLQKKSDVEDH |
| 60 | LSSYLQKKSDVEDHS |
Function
Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)
Protein Sequence
10
MAARRGALIV
20
LEGVDRAGKS
30
TQSRKLVEAL
40
CAAGHRAELL
50
RFPERSTEIG
60
KLLSSYLQKK
70
SDVEDHSVHL
80
LFSANRWEQV
90
PLIKEKLSQG
100
VTLVVDRYAF
110
SGVAFTGAKE
120
NFSLDWCKQP
130
DVGLPKPDLV
140
LFLQLQLADA
150
AKRGAFGHER
160
YENGAFQERA
170
LRCFHQLMKD
180
TTLNWKMVDA
190
SKSIEAVHED
200
IRVLSEDAIR
210
TATEKPLGEL
WK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004798 | dTMP kinase activity |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Biological Process | GO:0006233 | dTDP biosynthetic process |
| Biological Process | GO:0006235 | dTTP biosynthetic process |
| Biological Process | GO:0006227 | dUDP biosynthetic process |
| Biological Process | GO:0046105 | thymidine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.