Search Results
Overview
| Uniprot ID | P23927 |
|---|---|
| Protein Name | Alpha-crystallin B chain |
| Gene Name | Cryab |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | LTVNGPRKQVSGPER |
| 166 | IPITREEKPAVAAAP |
| 174 | PAVAAAPKK****** |
| 90 | HFSPEELKVKVLGDV |
| 92 | SPEELKVKVLGDVIE |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (PubMed:31786107)
Protein Sequence
10
MDIAIHHPWI
20
RRPFFPFHSP
30
SRLFDQFFGE
40
HLLESDLFST
50
ATSLSPFYLR
60
PPSFLRAPSW
70
IDTGLSEMRL
80
EKDRFSVNLD
90
VKHFSPEELK
100
VKVLGDVIEV
110
HGKHEERQDE
120
HGFISREFHR
130
KYRIPADVDP
140
LTITSSLSSD
150
GVLTVNGPRK
160
QVSGPERTIP
170
ITREEKPAVA
AAPKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032432 | actin filament bundle |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0060561 | apoptotic process involved in morphogenesis |
| Biological Process | GO:0043010 | camera-type eye development |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0002088 | lens development in camera-type eye |
| Biological Process | GO:0031109 | microtubule polymerization or depolymerization |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0032387 | negative regulation of intracellular transport |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0043067 | regulation of programmed cell death |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.