Search Results
Overview
| Uniprot ID | P24001 |
|---|---|
| Protein Name | Interleukin-32 |
| Gene Name | IL32 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 219 | YGAPRGDKEELTPQK |
| 226 | KEELTPQKCSEPQSS |
| 74 | AIERFYDKMQNAESG |
Function
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK
Protein Sequence
10
MCFPKVLSDD
20
MKKLKARMVM
30
LLPTSAQGLG
40
AWVSACDTED
50
TVGHLGPWRD
60
KDPALWCQLC
70
LSSQHQAIER
80
FYDKMQNAES
90
GRGQVMSSLA
100
ELEDDFKEGY
110
LETVAAYYEE
120
QHPELTPLLE
130
KERDGLRCRG
140
NRSPVPDVED
150
PATEEPGESF
160
CDKVMRWFQA
170
MLQRLQTWWH
180
GVLAWVKEKV
190
VALVHAVQAL
200
WKQFQSFCCS
210
LSELFMSSFQ
220
SYGAPRGDKE
230
ELTPQKCSEP
QSSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005125 | cytokine activity |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0006952 | defense response |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:1903901 | negative regulation of viral life cycle |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0034346 | positive regulation of type III interferon production |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.