Search Results

Overview

Uniprot IDP24043
Protein NameLaminin subunit alpha-2
Gene NameLAMA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 ITNAIDGKNTWWQSP

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Protein Sequence

10 MPGAAGVLLL 20 LLLSGGLGGV 30 QAQRPQQQRQ 40 SQAHQQRGLF 50 PAVLNLASNA 60 LITTNATCGE 70 KGPEMYCKLV 80 EHVPGQPVRN 90 PQCRICNQNS 100 SNPNQRHPIT 110 NAIDGKNTWW 120 QSPSIKNGIE 130 YHYVTITLDL 140 QQVFQIAYVI 150 VKAANSPRPG 160 NWILERSLDD 170 VEYKPWQYHA 180 VTDTECLTLY 190 NIYPRTGPPS 200 YAKDDEVICT 210 SFYSKIHPLE 220 NGEIHISLIN 230 GRPSADDPSP 240 ELLEFTSARY 250 IRLRFQRIRT 260 LNADLMMFAH 270 KDPREIDPIV 280 TRRYYYSVKD 290 ISVGGMCICY 300 GHARACPLDP 310 ATNKSRCECE 320 HNTCGDSCDQ 330 CCPGFHQKPW 340 RAGTFLTKTE 350 CEACNCHGKA 360 EECYYDENVA 370 RRNLSLNIRG 380 KYIGGGVCIN 390 CTQNTAGINC 400 ETCTDGFFRP 410 KGVSPNYPRP 420 CQPCHCDPIG 430 SLNEVCVKDE 440 KHARRGLAPG 450 SCHCKTGFGG 460 VSCDRCARGY 470 TGYPDCKACN 480 CSGLGSKNED 490 PCFGPCICKE 500 NVEGGDCSRC 510 KSGFFNLQED 520 NWKGCDECFC 530 SGVSNRCQSS 540 YWTYGKIQDM 550 SGWYLTDLPG 560 RIRVAPQQDD 570 LDSPQQISIS 580 NAEARQALPH 590 SYYWSAPAPY 600 LGNKLPAVGG 610 QLTFTISYDL 620 EEEEEDTERV 630 LQLMIILEGN 640 DLSISTAQDE 650 VYLHPSEEHT 660 NVLLLKEESF 670 TIHGTHFPVR 680 RKEFMTVLAN 690 LKRVLLQITY 700 SFGMDAIFRL 710 SSVNLESAVS 720 YPTDGSIAAA 730 VEVCQCPPGY 740 TGSSCESCWP 750 RHRRVNGTIF 760 GGICEPCQCF 770 GHAESCDDVT 780 GECLNCKDHT 790 GGPYCDKCLP 800 GFYGEPTKGT 810 SEDCQPCACP 820 LNIPSNNFSP 830 TCHLDRSLGL 840 ICDGCPVGYT 850 GPRCERCAEG 860 YFGQPSVPGG 870 SCQPCQCNDN 880 LDFSIPGSCD 890 SLSGSCLICK 900 PGTTGRYCEL 910 CADGYFGDAV 920 DAKNCQPCRC 930 NAGGSFSEVC 940 HSQTGQCECR 950 ANVQGQRCDK 960 CKAGTFGLQS 970 ARGCVPCNCN 980 SFGSKSFDCE 990 ESGQCWCQPG 1000 VTGKKCDRCA 1010 HGYFNFQEGG 1020 CTACECSHLG 1030 NNCDPKTGRC 1040 ICPPNTIGEK 1050 CSKCAPNTWG 1060 HSITTGCKAC 1070 NCSTVGSLDF 1080 QCNVNTGQCN 1090 CHPKFSGAKC 1100 TECSRGHWNY 1110 PRCNLCDCFL 1120 PGTDATTCDS 1130 ETKKCSCSDQ 1140 TGQCTCKVNV 1150 EGIHCDRCRP 1160 GKFGLDAKNP 1170 LGCSSCYCFG 1180 TTTQCSEAKG 1190 LIRTWVTLKA 1200 EQTILPLVDE 1210 ALQHTTTKGI 1220 VFQHPEIVAH 1230 MDLMREDLHL 1240 EPFYWKLPEQ 1250 FEGKKLMAYG 1260 GKLKYAIYFE 1270 AREETGFSTY 1280 NPQVIIRGGT 1290 PTHARIIVRH 1300 MAAPLIGQLT 1310 RHEIEMTEKE 1320 WKYYGDDPRV 1330 HRTVTREDFL 1340 DILYDIHYIL 1350 IKATYGNFMR 1360 QSRISEISME 1370 VAEQGRGTTM 1380 TPPADLIEKC 1390 DCPLGYSGLS 1400 CEACLPGFYR 1410 LRSQPGGRTP 1420 GPTLGTCVPC 1430 QCNGHSSLCD 1440 PETSICQNCQ 1450 HHTAGDFCER 1460 CALGYYGIVK 1470 GLPNDCQQCA 1480 CPLISSSNNF 1490 SPSCVAEGLD 1500 DYRCTACPRG 1510 YEGQYCERCA 1520 PGYTGSPGNP 1530 GGSCQECECD 1540 PYGSLPVPCD 1550 PVTGFCTCRP 1560 GATGRKCDGC 1570 KHWHAREGWE 1580 CVFCGDECTG 1590 LLLGDLARLE 1600 QMVMSINLTG 1610 PLPAPYKMLY 1620 GLENMTQELK 1630 HLLSPQRAPE 1640 RLIQLAEGNL 1650 NTLVTEMNEL 1660 LTRATKVTAD 1670 GEQTGQDAER 1680 TNTRAKSLGE 1690 FIKELARDAE 1700 AVNEKAIKLN 1710 ETLGTRDEAF 1720 ERNLEGLQKE 1730 IDQMIKELRR 1740 KNLETQKEIA 1750 EDELVAAEAL 1760 LKKVKKLFGE 1770 SRGENEEMEK 1780 DLREKLADYK 1790 NKVDDAWDLL 1800 REATDKIREA 1810 NRLFAVNQKN 1820 MTALEKKKEA 1830 VESGKRQIEN 1840 TLKEGNDILD 1850 EANRLADEIN 1860 SIIDYVEDIQ 1870 TKLPPMSEEL 1880 NDKIDDLSQE 1890 IKDRKLAEKV 1900 SQAESHAAQL 1910 NDSSAVLDGI 1920 LDEAKNISFN 1930 ATAAFKAYSN 1940 IKDYIDEAEK 1950 VAKEAKDLAH 1960 EATKLATGPR 1970 GLLKEDAKGC 1980 LQKSFRILNE 1990 AKKLANDVKE 2000 NEDHLNGLKT 2010 RIENADARNG 2020 DLLRTLNDTL 2030 GKLSAIPNDT 2040 AAKLQAVKDK 2050 ARQANDTAKD 2060 VLAQITELHQ 2070 NLDGLKKNYN 2080 KLADSVAKTN 2090 AVVKDPSKNK 2100 IIADADATVK 2110 NLEQEADRLI 2120 DKLKPIKELE 2130 DNLKKNISEI 2140 KELINQARKQ 2150 ANSIKVSVSS 2160 GGDCIRTYKP 2170 EIKKGSYNNI 2180 VVNVKTAVAD 2190 NLLFYLGSAK 2200 FIDFLAIEMR 2210 KGKVSFLWDV 2220 GSGVGRVEYP 2230 DLTIDDSYWY 2240 RIVASRTGRN 2250 GTISVRALDG 2260 PKASIVPSTH 2270 HSTSPPGYTI 2280 LDVDANAMLF 2290 VGGLTGKLKK 2300 ADAVRVITFT 2310 GCMGETYFDN 2320 KPIGLWNFRE 2330 KEGDCKGCTV 2340 SPQVEDSEGT 2350 IQFDGEGYAL 2360 VSRPIRWYPN 2370 ISTVMFKFRT 2380 FSSSALLMYL 2390 ATRDLRDFMS 2400 VELTDGHIKV 2410 SYDLGSGMAS 2420 VVSNQNHNDG 2430 KWKSFTLSRI 2440 QKQANISIVD 2450 IDTNQEENIA 2460 TSSSGNNFGL 2470 DLKADDKIYF 2480 GGLPTLRNLS 2490 MKARPEVNLK 2500 KYSGCLKDIE 2510 ISRTPYNILS 2520 SPDYVGVTKG 2530 CSLENVYTVS 2540 FPKPGFVELS 2550 PVPIDVGTEI 2560 NLSFSTKNES 2570 GIILLGSGGT 2580 PAPPRRKRRQ 2590 TGQAYYAILL 2600 NRGRLEVHLS 2610 TGARTMRKIV 2620 IRPEPNLFHD 2630 GREHSVHVER 2640 TRGIFTVQVD 2650 ENRRYMQNLT 2660 VEQPIEVKKL 2670 FVGGAPPEFQ 2680 PSPLRNIPPF 2690 EGCIWNLVIN 2700 SVPMDFARPV 2710 SFKNADIGRC 2720 AHQKLREDED 2730 GAAPAEIVIQ 2740 PEPVPTPAFP 2750 TPTPVLTHGP 2760 CAAESEPALL 2770 IGSKQFGLSR 2780 NSHIAIAFDD 2790 TKVKNRLTIE 2800 LEVRTEAESG 2810 LLFYMARINH 2820 ADFATVQLRN 2830 GLPYFSYDLG 2840 SGDTHTMIPT 2850 KINDGQWHKI 2860 KIMRSKQEGI 2870 LYVDGASNRT 2880 ISPKKADILD 2890 VVGMLYVGGL 2900 PINYTTRRIG 2910 PVTYSIDGCV 2920 RNLHMAEAPA 2930 DLEQPTSSFH 2940 VGTCFANAQR 2950 GTYFDGTGFA 2960 KAVGGFKVGL 2970 DLLVEFEFRT 2980 TTTTGVLLGI 2990 SSQKMDGMGI 3000 EMIDEKLMFH 3010 VDNGAGRFTA 3020 VYDAGVPGHL 3030 CDGQWHKVTA 3040 NKIKHRIELT 3050 VDGNQVEAQS 3060 PNPASTSADT 3070 NDPVFVGGFP 3080 DDLKQFGLTT 3090 SIPFRGCIRS 3100 LKLTKGTGKP 3110 LEVNFAKALE 3120 LRGVQPVSCP AN

Gene Ontology

Classification GO ID Description
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005607 laminin-211 trimer
Cellular Component GO:0043261 laminin-213 trimer
Cellular Component GO:0005609 laminin-221 trimer
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0045202 synapse
Cellular Component GO:0043083 synaptic cleft
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0007155 cell adhesion
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0007517 muscle organ development
Biological Process GO:0007399 nervous system development
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:0110011 regulation of basement membrane organization
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0007165 signal transduction

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.