Search Results
Overview
| Uniprot ID | P24268 |
|---|---|
| Protein Name | Cathepsin D |
| Gene Name | Ctsd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 171 | LGGIKVEKQIFGEAT |
| 352 | HPEKYILKVSQAGKT |
Function
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation
Protein Sequence
10
MQTPGVLLLI
20
LGLLDASSSA
30
LIRIPLRKFT
40
SIRRTMTEVG
50
GSVEDLILKG
60
PITKYSMQSS
70
PRTKEPVSEL
80
LKNYLDAQYY
90
GEIGIGTPPQ
100
CFTVVFDTGS
110
SNLWVPSIHC
120
KLLDIACWVH
130
HKYNSDKSST
140
YVKNGTSFDI
150
HYGSGSLSGY
160
LSQDTVSVPC
170
KSDLGGIKVE
180
KQIFGEATKQ
190
PGVVFIAAKF
200
DGILGMGYPF
210
ISVNKVLPVF
220
DNLMKQKLVE
230
KNIFSFYLNR
240
DPTGQPGGEL
250
MLGGTDSRYY
260
HGELSYLNVT
270
RKAYWQVHMD
280
QLEVGSELTL
290
CKGGCEAIVD
300
TGTSLLVGPV
310
DEVKELQKAI
320
GAVPLIQGEY
330
MIPCEKVSSL
340
PIITFKLGGQ
350
NYELHPEKYI
360
LKVSQAGKTI
370
CLSGFMGMDI
380
PPPSGPLWIL
390
GDVFIGCYYT
400
VFDREYNRVG
FAKAATL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004175 | endopeptidase activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031904 | endosome lumen |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0098830 | presynaptic endosome |
| Molecular Function | GO:0004190 | aspartic-type endopeptidase activity |
| Molecular Function | GO:0070001 | aspartic-type peptidase activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0042277 | peptide binding |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0097194 | execution phase of apoptosis |
| Biological Process | GO:1901143 | insulin catabolic process |
| Biological Process | GO:0038020 | insulin receptor recycling |
| Biological Process | GO:0042159 | lipoprotein catabolic process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030163 | protein catabolic process |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0070201 | regulation of establishment of protein localization |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0099532 | synaptic vesicle endosomal processing |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.