Search Results
Overview
| Uniprot ID | P24298 |
|---|---|
| Protein Name | Alanine aminotransferase 1 |
| Gene Name | GPT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | VRHGLRAKVLTLDGM |
| 389 | VLAELAAKAKLTEQV |
| 58 | ELRQGVKKPFTEVIR |
Function
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)
Protein Sequence
10
MASSTGDRSQ
20
AVRHGLRAKV
30
LTLDGMNPRV
40
RRVEYAVRGP
50
IVQRALELEQ
60
ELRQGVKKPF
70
TEVIRANIGD
80
AQAMGQRPIT
90
FLRQVLALCV
100
NPDLLSSPNF
110
PDDAKKRAER
120
ILQACGGHSL
130
GAYSVSSGIQ
140
LIREDVARYI
150
ERRDGGIPAD
160
PNNVFLSTGA
170
SDAIVTVLKL
180
LVAGEGHTRT
190
GVLIPIPQYP
200
LYSATLAELG
210
AVQVDYYLDE
220
ERAWALDVAE
230
LHRALGQARD
240
HCRPRALCVI
250
NPGNPTGQVQ
260
TRECIEAVIR
270
FAFEERLFLL
280
ADEVYQDNVY
290
AAGSQFHSFK
300
KVLMEMGPPY
310
AGQQELASFH
320
STSKGYMGEC
330
GFRGGYVEVV
340
NMDAAVQQQM
350
LKLMSVRLCP
360
PVPGQALLDL
370
VVSPPAPTDP
380
SFAQFQAEKQ
390
AVLAELAAKA
400
KLTEQVFNEA
410
PGISCNPVQG
420
AMYSFPRVQL
430
PPRAVERAQE
440
LGLAPDMFFC
450
LRLLEETGIC
460
VVPGSGFGQR
470
EGTYHFRMTI
480
LPPLEKLRLL
490
LEKLSRFHAK
FTLEYS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0042853 | L-alanine catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.