Search Results
Overview
| Uniprot ID | P24368 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase B |
| Gene Name | Ppib |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | RGDGTGGKSIYGERF |
| 129 | RFPDENFKLKHYGPG |
| 131 | PDENFKLKHYGPGWV |
| 165 | KTSWLDGKHVVFGKV |
| 171 | GKHVVFGKVLEGMDV |
| 186 | VRKVENTKTDSRDKP |
| 195 | DSRDKPLKDVIIVDC |
| 209 | CGKIEVEKPFAIAKE |
| 215 | EKPFAIAKE****** |
| 67 | VTFGLFGKTVPKTVD |
| 89 | GEKGFGYKNSKFHRV |
| 98 | SKFHRVIKDFMIQGG |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding
Protein Sequence
10
MLRLSERNMK
20
VLFAAALIVG
30
SVVFLLLPGP
40
SVANDKKKGP
50
KVTVKVYFDF
60
QIGDEPVGRV
70
TFGLFGKTVP
80
KTVDNFVALA
90
TGEKGFGYKN
100
SKFHRVIKDF
110
MIQGGDFTRG
120
DGTGGKSIYG
130
ERFPDENFKL
140
KHYGPGWVSM
150
ANAGKDTNGS
160
QFFITTVKTS
170
WLDGKHVVFG
180
KVLEGMDVVR
190
KVENTKTDSR
200
DKPLKDVIIV
210
DCGKIEVEKP
FAIAKE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0034663 | endoplasmic reticulum chaperone complex |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Molecular Function | GO:0016018 | cyclosporin A binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0070063 | RNA polymerase binding |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0044829 | host-mediated activation of viral genome replication |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0030593 | neutrophil chemotaxis |
| Biological Process | GO:0051169 | nuclear transport |
| Biological Process | GO:0040018 | positive regulation of multicellular organism growth |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.