Search Results

Overview

Uniprot IDP24534
Protein NameElongation factor 1-beta
Gene NameEEF1B2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
129 RLAQYESKKAKKPAL
130 LAQYESKKAKKPALV
185 VPVGYGIKKLQIQCV
186 PVGYGIKKLQIQCVV
66 IKSYEKEKASLPGVK
73 KASLPGVKKALGKYG
74 ASLPGVKKALGKYGP
78 GVKKALGKYGPADVE

Function

Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity)

Protein Sequence

10 MGFGDLKSPA 20 GLQVLNDYLA 30 DKSYIEGYVP 40 SQADVAVFEA 50 VSSPPPADLC 60 HALRWYNHIK 70 SYEKEKASLP 80 GVKKALGKYG 90 PADVEDTTGS 100 GATDSKDDDD 110 IDLFGSDDEE 120 ESEEAKRLRE 130 ERLAQYESKK 140 AKKPALVAKS 150 SILLDVKPWD 160 DETDMAKLEE 170 CVRSIQADGL 180 VWGSSKLVPV 190 GYGIKKLQIQ 200 CVVEDDKVGT 210 DMLEEQITAF 220 EDYVQSMDVA AFNKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005853 eukaryotic translation elongation factor 1 complex
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0045471 response to ethanol
Biological Process GO:0006414 translational elongation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.