Overview
| Uniprot ID | P24557 |
|---|
| Protein Name | Thromboxane-A synthase |
|---|
| Gene Name | TBXAS1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 529 |
PKNGVYIKIVSR*** |
Function
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323)
Protein Sequence
10
MEALGFLKLE
20
VNGPMVTVAL
30
SVALLALLKW
40
YSTSAFSRLE
50
KLGLRHPKPS
60
PFIGNLTFFR
70
QGFWESQMEL
80
RKLYGPLCGY
90
YLGRRMFIVI
100
SEPDMIKQVL
110
VENFSNFTNR
120
MASGLEFKSV
130
ADSVLFLRDK
140
RWEEVRGALM
150
SAFSPEKLNE
160
MVPLISQACD
170
LLLAHLKRYA
180
ESGDAFDIQR
190
CYCNYTTDVV
200
ASVAFGTPVD
210
SWQAPEDPFV
220
KHCKRFFEFC
230
IPRPILVLLL
240
SFPSIMVPLA
250
RILPNKNRDE
260
LNGFFNKLIR
270
NVIALRDQQA
280
AEERRRDFLQ
290
MVLDARHSAS
300
PMGVQDFDIV
310
RDVFSSTGCK
320
PNPSRQHQPS
330
PMARPLTVDE
340
IVGQAFIFLI
350
AGYEIITNTL
360
SFATYLLATN
370
PDCQEKLLRE
380
VDVFKEKHMA
390
PEFCSLEEGL
400
PYLDMVIAET
410
LRMYPPAFRF
420
TREAAQDCEV
430
LGQRIPAGAV
440
LEMAVGALHH
450
DPEHWPSPET
460
FNPERFTAEA
470
RQQHRPFTYL
480
PFGAGPRSCL
490
GVRLGLLEVK
500
LTLLHVLHKF
510
RFQACPETQV
520
PLQLESKSAL
530
GPKNGVYIKI
VSR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0036134 |
12-hydroxyheptadecatrienoic acid synthase activity |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0106256 |
hydroperoxy icosatetraenoate dehydratase activity |
| Molecular Function |
GO:0005506 |
iron ion binding |
| Molecular Function |
GO:0004497 |
monooxygenase activity |
| Molecular Function |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| Molecular Function |
GO:0004796 |
thromboxane-A synthase activity |
| Biological Process |
GO:0006690 |
icosanoid metabolic process |
| Biological Process |
GO:0030644 |
intracellular chloride ion homeostasis |
| Biological Process |
GO:0045907 |
positive regulation of vasoconstriction |
| Biological Process |
GO:0001516 |
prostaglandin biosynthetic process |
| Biological Process |
GO:0046457 |
prostanoid biosynthetic process |
| Biological Process |
GO:0045471 |
response to ethanol |
| Biological Process |
GO:0070542 |
response to fatty acid |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.