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Overview

Uniprot ID	P24666
Protein Name	Low molecular weight phosphotyrosine protein phosphatase
Gene Name	ACP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	NRKSNQVKTCKAKIE

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2

Protein Sequence

10 MAEQATKSVL 20 FVCLGNICRS 30 PIAEAVFRKL 40 VTDQNISENW 50 RVDSAATSGY 60 EIGNPPDYRG 70 QSCMKRHGIP 80 MSHVARQITK 90 EDFATFDYIL 100 CMDESNLRDL 110 NRKSNQVKTC 120 KAKIELLGSY 130 DPQKQLIIED 140 PYYGNDSDFE 150 TVYQQCVRCC RAFLEKAH

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0042383	sarcolemma
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0003993	acid phosphatase activity
Molecular Function	GO:0004725	protein tyrosine phosphatase activity
Molecular Function	GO:0017124	SH3 domain binding
Biological Process	GO:0007268	chemical synaptic transmission

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.