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Overview

Uniprot IDP24821
Protein NameTenascin
Gene NameTNC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1057 NVLLTAEKGRHKSKP
120 CAAAPDVKELLSRLE
1882 KSSTITAKFTTDLDS
699 VFAILENKKSIPVSA
700 FAILENKKSIPVSAR
719 LPAPEGLKFKSIKET

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)

Protein Sequence

10 MGAMTQLLAG 20 VFLAFLALAT 30 EGGVLKKVIR 40 HKRQSGVNAT 50 LPEENQPVVF 60 NHVYNIKLPV 70 GSQCSVDLES 80 ASGEKDLAPP 90 SEPSESFQEH 100 TVDGENQIVF 110 THRINIPRRA 120 CGCAAAPDVK 130 ELLSRLEELE 140 NLVSSLREQC 150 TAGAGCCLQP 160 ATGRLDTRPF 170 CSGRGNFSTE 180 GCGCVCEPGW 190 KGPNCSEPEC 200 PGNCHLRGRC 210 IDGQCICDDG 220 FTGEDCSQLA 230 CPSDCNDQGK 240 CVNGVCICFE 250 GYAGADCSRE 260 ICPVPCSEEH 270 GTCVDGLCVC 280 HDGFAGDDCN 290 KPLCLNNCYN 300 RGRCVENECV 310 CDEGFTGEDC 320 SELICPNDCF 330 DRGRCINGTC 340 YCEEGFTGED 350 CGKPTCPHAC 360 HTQGRCEEGQ 370 CVCDEGFAGV 380 DCSEKRCPAD 390 CHNRGRCVDG 400 RCECDDGFTG 410 ADCGELKCPN 420 GCSGHGRCVN 430 GQCVCDEGYT 440 GEDCSQLRCP 450 NDCHSRGRCV 460 EGKCVCEQGF 470 KGYDCSDMSC 480 PNDCHQHGRC 490 VNGMCVCDDG 500 YTGEDCRDRQ 510 CPRDCSNRGL 520 CVDGQCVCED 530 GFTGPDCAEL 540 SCPNDCHGQG 550 RCVNGQCVCH 560 EGFMGKDCKE 570 QRCPSDCHGQ 580 GRCVDGQCIC 590 HEGFTGLDCG 600 QHSCPSDCNN 610 LGQCVSGRCI 620 CNEGYSGEDC 630 SEVSPPKDLV 640 VTEVTEETVN 650 LAWDNEMRVT 660 EYLVVYTPTH 670 EGGLEMQFRV 680 PGDQTSTIIQ 690 ELEPGVEYFI 700 RVFAILENKK 710 SIPVSARVAT 720 YLPAPEGLKF 730 KSIKETSVEV 740 EWDPLDIAFE 750 TWEIIFRNMN 760 KEDEGEITKS 770 LRRPETSYRQ 780 TGLAPGQEYE 790 ISLHIVKNNT 800 RGPGLKRVTT 810 TRLDAPSQIE 820 VKDVTDTTAL 830 ITWFKPLAEI 840 DGIELTYGIK 850 DVPGDRTTID 860 LTEDENQYSI 870 GNLKPDTEYE 880 VSLISRRGDM 890 SSNPAKETFT 900 TGLDAPRNLR 910 RVSQTDNSIT 920 LEWRNGKAAI 930 DSYRIKYAPI 940 SGGDHAEVDV 950 PKSQQATTKT 960 TLTGLRPGTE 970 YGIGVSAVKE 980 DKESNPATIN 990 AATELDTPKD 1000 LQVSETAETS 1010 LTLLWKTPLA 1020 KFDRYRLNYS 1030 LPTGQWVGVQ 1040 LPRNTTSYVL 1050 RGLEPGQEYN 1060 VLLTAEKGRH 1070 KSKPARVKAS 1080 TEQAPELENL 1090 TVTEVGWDGL 1100 RLNWTAADQA 1110 YEHFIIQVQE 1120 ANKVEAARNL 1130 TVPGSLRAVD 1140 IPGLKAATPY 1150 TVSIYGVIQG 1160 YRTPVLSAEA 1170 STGETPNLGE 1180 VVVAEVGWDA 1190 LKLNWTAPEG 1200 AYEYFFIQVQ 1210 EADTVEAAQN 1220 LTVPGGLRST 1230 DLPGLKAATH 1240 YTITIRGVTQ 1250 DFSTTPLSVE 1260 VLTEEVPDMG 1270 NLTVTEVSWD 1280 ALRLNWTTPD 1290 GTYDQFTIQV 1300 QEADQVEEAH 1310 NLTVPGSLRS 1320 MEIPGLRAGT 1330 PYTVTLHGEV 1340 RGHSTRPLAV 1350 EVVTEDLPQL 1360 GDLAVSEVGW 1370 DGLRLNWTAA 1380 DNAYEHFVIQ 1390 VQEVNKVEAA 1400 QNLTLPGSLR 1410 AVDIPGLEAA 1420 TPYRVSIYGV 1430 IRGYRTPVLS 1440 AEASTAKEPE 1450 IGNLNVSDIT 1460 PESFNLSWMA 1470 TDGIFETFTI 1480 EIIDSNRLLE 1490 TVEYNISGAE 1500 RTAHISGLPP 1510 STDFIVYLSG 1520 LAPSIRTKTI 1530 SATATTEALP 1540 LLENLTISDI 1550 NPYGFTVSWM 1560 ASENAFDSFL 1570 VTVVDSGKLL 1580 DPQEFTLSGT 1590 QRKLELRGLI 1600 TGIGYEVMVS 1610 GFTQGHQTKP 1620 LRAEIVTEAE 1630 PEVDNLLVSD 1640 ATPDGFRLSW 1650 TADEGVFDNF 1660 VLKIRDTKKQ 1670 SEPLEITLLA 1680 PERTRDITGL 1690 REATEYEIEL 1700 YGISKGRRSQ 1710 TVSAIATTAM 1720 GSPKEVIFSD 1730 ITENSATVSW 1740 RAPTAQVESF 1750 RITYVPITGG 1760 TPSMVTVDGT 1770 KTQTRLVKLI 1780 PGVEYLVSII 1790 AMKGFEESEP 1800 VSGSFTTALD 1810 GPSGLVTANI 1820 TDSEALARWQ 1830 PAIATVDSYV 1840 ISYTGEKVPE 1850 ITRTVSGNTV 1860 EYALTDLEPA 1870 TEYTLRIFAE 1880 KGPQKSSTIT 1890 AKFTTDLDSP 1900 RDLTATEVQS 1910 ETALLTWRPP 1920 RASVTGYLLV 1930 YESVDGTVKE 1940 VIVGPDTTSY 1950 SLADLSPSTH 1960 YTAKIQALNG 1970 PLRSNMIQTI 1980 FTTIGLLYPF 1990 PKDCSQAMLN 2000 GDTTSGLYTI 2010 YLNGDKAEAL 2020 EVFCDMTSDG 2030 GGWIVFLRRK 2040 NGRENFYQNW 2050 KAYAAGFGDR 2060 REEFWLGLDN 2070 LNKITAQGQY 2080 ELRVDLRDHG 2090 ETAFAVYDKF 2100 SVGDAKTRYK 2110 LKVEGYSGTA 2120 GDSMAYHNGR 2130 SFSTFDKDTD 2140 SAITNCALSY 2150 KGAFWYRNCH 2160 RVNLMGRYGD 2170 NNHSQGVNWF 2180 HWKGHEHSIQ 2190 FAEMKLRPSN 2200 FRNLEGRRKR A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005614 interstitial matrix
Cellular Component GO:0016020 membrane
Cellular Component GO:0098966 perisynaptic extracellular matrix
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0045545 syndecan binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0002009 morphogenesis of an epithelium
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0009611 response to wounding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.