Search Results
Overview
| Uniprot ID | P24942 |
|---|---|
| Protein Name | Excitatory amino acid transporter 1 |
| Gene Name | Slc1a3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 152 | IHPGKGTKENMYREG |
| 32 | RTLLAKKKVQNITKE |
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity)
Protein Sequence
10
MTKSNGEEPR
20
MGSRMERFQQ
30
GVRKRTLLAK
40
KKVQNITKED
50
VKSYLFRNAF
60
VLLTVSAVIV
70
GTILGFALRP
80
YKMSYREVKY
90
FSFPGELLMR
100
MLQMLVLPLI
110
ISSLVTGMAA
120
LDSKASGKMG
130
MRAVVYYMTT
140
TIIAVVIGII
150
IVIIIHPGKG
160
TKENMYREGK
170
IVQVTAADAF
180
LDLIRNMFPP
190
NLVEACFKQF
200
KTSYEKRSFK
210
VPIQANETLL
220
GAVINNVSEA
230
METLTRIREE
240
MVPVPGSVNG
250
VNALGLVVFS
260
MCFGFVIGNM
270
KEQGQALREF
280
FDSLNEAIMR
290
LVAVIMWYAP
300
LGILFLIAGK
310
ILEMEDMGVI
320
GGQLAMYTVT
330
VIVGLLIHAV
340
IVLPLLYFLV
350
TRKNPWVFIG
360
GLLQALITAL
370
GTSSSSATLP
380
ITFKCLEENN
390
GVDKRITRFV
400
LPVGATINMD
410
GTALYEALAA
420
IFIAQVNNFD
430
LNFGQIITIS
440
ITATAASIGA
450
AGIPQAGLVT
460
MVIVLTSVGL
470
PTDDITLIIA
480
VDWFLDRLRT
490
TTNVLGDSLG
500
AGIVEHLSRH
510
ELKNRDVEMG
520
NSVIEENEMK
530
KPYQLIAQDN
540
EPEKPVADSE
TKM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009925 | basal plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098796 | membrane protein complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0015172 | acidic amino acid transmembrane transporter activity |
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0016595 | glutamate binding |
| Molecular Function | GO:0015501 | glutamate:sodium symporter activity |
| Molecular Function | GO:0005314 | high-affinity L-glutamate transmembrane transporter activity |
| Molecular Function | GO:0005313 | L-glutamate transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0015175 | neutral L-amino acid transmembrane transporter activity |
| Biological Process | GO:0031223 | auditory behavior |
| Biological Process | GO:0048667 | cell morphogenesis involved in neuron differentiation |
| Biological Process | GO:0071314 | cellular response to cocaine |
| Biological Process | GO:1902476 | chloride transmembrane transport |
| Biological Process | GO:0021545 | cranial nerve development |
| Biological Process | GO:0070779 | D-aspartate import across plasma membrane |
| Biological Process | GO:0009449 | gamma-aminobutyric acid biosynthetic process |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0140009 | L-aspartate import across plasma membrane |
| Biological Process | GO:0051938 | L-glutamate import |
| Biological Process | GO:0098712 | L-glutamate import across plasma membrane |
| Biological Process | GO:0015813 | L-glutamate transmembrane transport |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0050885 | neuromuscular process controlling balance |
| Biological Process | GO:0006836 | neurotransmitter transport |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0046677 | response to antibiotic |
| Biological Process | GO:0009416 | response to light stimulus |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.