Search Results
Overview
| Uniprot ID | P25054 |
|---|---|
| Protein Name | Adenomatous polyposis coli protein |
| Gene Name | APC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 2386 | TKQTGLSKNASSIPR |
Function
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization
Protein Sequence
10
MAAASYDQLL
20
KQVEALKMEN
30
SNLRQELEDN
40
SNHLTKLETE
50
ASNMKEVLKQ
60
LQGSIEDEAM
70
ASSGQIDLLE
80
RLKELNLDSS
90
NFPGVKLRSK
100
MSLRSYGSRE
110
GSVSSRSGEC
120
SPVPMGSFPR
130
RGFVNGSRES
140
TGYLEELEKE
150
RSLLLADLDK
160
EEKEKDWYYA
170
QLQNLTKRID
180
SLPLTENFSL
190
QTDMTRRQLE
200
YEARQIRVAM
210
EEQLGTCQDM
220
EKRAQRRIAR
230
IQQIEKDILR
240
IRQLLQSQAT
250
EAERSSQNKH
260
ETGSHDAERQ
270
NEGQGVGEIN
280
MATSGNGQGS
290
TTRMDHETAS
300
VLSSSSTHSA
310
PRRLTSHLGT
320
KVEMVYSLLS
330
MLGTHDKDDM
340
SRTLLAMSSS
350
QDSCISMRQS
360
GCLPLLIQLL
370
HGNDKDSVLL
380
GNSRGSKEAR
390
ARASAALHNI
400
IHSQPDDKRG
410
RREIRVLHLL
420
EQIRAYCETC
430
WEWQEAHEPG
440
MDQDKNPMPA
450
PVEHQICPAV
460
CVLMKLSFDE
470
EHRHAMNELG
480
GLQAIAELLQ
490
VDCEMYGLTN
500
DHYSITLRRY
510
AGMALTNLTF
520
GDVANKATLC
530
SMKGCMRALV
540
AQLKSESEDL
550
QQVIASVLRN
560
LSWRADVNSK
570
KTLREVGSVK
580
ALMECALEVK
590
KESTLKSVLS
600
ALWNLSAHCT
610
ENKADICAVD
620
GALAFLVGTL
630
TYRSQTNTLA
640
IIESGGGILR
650
NVSSLIATNE
660
DHRQILRENN
670
CLQTLLQHLK
680
SHSLTIVSNA
690
CGTLWNLSAR
700
NPKDQEALWD
710
MGAVSMLKNL
720
IHSKHKMIAM
730
GSAAALRNLM
740
ANRPAKYKDA
750
NIMSPGSSLP
760
SLHVRKQKAL
770
EAELDAQHLS
780
ETFDNIDNLS
790
PKASHRSKQR
800
HKQSLYGDYV
810
FDTNRHDDNR
820
SDNFNTGNMT
830
VLSPYLNTTV
840
LPSSSSSRGS
850
LDSSRSEKDR
860
SLERERGIGL
870
GNYHPATENP
880
GTSSKRGLQI
890
STTAAQIAKV
900
MEEVSAIHTS
910
QEDRSSGSTT
920
ELHCVTDERN
930
ALRRSSAAHT
940
HSNTYNFTKS
950
ENSNRTCSMP
960
YAKLEYKRSS
970
NDSLNSVSSS
980
DGYGKRGQMK
990
PSIESYSEDD
1000
ESKFCSYGQY
1010
PADLAHKIHS
1020
ANHMDDNDGE
1030
LDTPINYSLK
1040
YSDEQLNSGR
1050
QSPSQNERWA
1060
RPKHIIEDEI
1070
KQSEQRQSRN
1080
QSTTYPVYTE
1090
STDDKHLKFQ
1100
PHFGQQECVS
1110
PYRSRGANGS
1120
ETNRVGSNHG
1130
INQNVSQSLC
1140
QEDDYEDDKP
1150
TNYSERYSEE
1160
EQHEEEERPT
1170
NYSIKYNEEK
1180
RHVDQPIDYS
1190
LKYATDIPSS
1200
QKQSFSFSKS
1210
SSGQSSKTEH
1220
MSSSSENTST
1230
PSSNAKRQNQ
1240
LHPSSAQSRS
1250
GQPQKAATCK
1260
VSSINQETIQ
1270
TYCVEDTPIC
1280
FSRCSSLSSL
1290
SSAEDEIGCN
1300
QTTQEADSAN
1310
TLQIAEIKEK
1320
IGTRSAEDPV
1330
SEVPAVSQHP
1340
RTKSSRLQGS
1350
SLSSESARHK
1360
AVEFSSGAKS
1370
PSKSGAQTPK
1380
SPPEHYVQET
1390
PLMFSRCTSV
1400
SSLDSFESRS
1410
IASSVQSEPC
1420
SGMVSGIISP
1430
SDLPDSPGQT
1440
MPPSRSKTPP
1450
PPPQTAQTKR
1460
EVPKNKAPTA
1470
EKRESGPKQA
1480
AVNAAVQRVQ
1490
VLPDADTLLH
1500
FATESTPDGF
1510
SCSSSLSALS
1520
LDEPFIQKDV
1530
ELRIMPPVQE
1540
NDNGNETESE
1550
QPKESNENQE
1560
KEAEKTIDSE
1570
KDLLDDSDDD
1580
DIEILEECII
1590
SAMPTKSSRK
1600
AKKPAQTASK
1610
LPPPVARKPS
1620
QLPVYKLLPS
1630
QNRLQPQKHV
1640
SFTPGDDMPR
1650
VYCVEGTPIN
1660
FSTATSLSDL
1670
TIESPPNELA
1680
AGEGVRGGAQ
1690
SGEFEKRDTI
1700
PTEGRSTDEA
1710
QGGKTSSVTI
1720
PELDDNKAEE
1730
GDILAECINS
1740
AMPKGKSHKP
1750
FRVKKIMDQV
1760
QQASASSSAP
1770
NKNQLDGKKK
1780
KPTSPVKPIP
1790
QNTEYRTRVR
1800
KNADSKNNLN
1810
AERVFSDNKD
1820
SKKQNLKNNS
1830
KVFNDKLPNN
1840
EDRVRGSFAF
1850
DSPHHYTPIE
1860
GTPYCFSRND
1870
SLSSLDFDDD
1880
DVDLSREKAE
1890
LRKAKENKES
1900
EAKVTSHTEL
1910
TSNQQSANKT
1920
QAIAKQPINR
1930
GQPKPILQKQ
1940
STFPQSSKDI
1950
PDRGAATDEK
1960
LQNFAIENTP
1970
VCFSHNSSLS
1980
SLSDIDQENN
1990
NKENEPIKET
2000
EPPDSQGEPS
2010
KPQASGYAPK
2020
SFHVEDTPVC
2030
FSRNSSLSSL
2040
SIDSEDDLLQ
2050
ECISSAMPKK
2060
KKPSRLKGDN
2070
EKHSPRNMGG
2080
ILGEDLTLDL
2090
KDIQRPDSEH
2100
GLSPDSENFD
2110
WKAIQEGANS
2120
IVSSLHQAAA
2130
AACLSRQASS
2140
DSDSILSLKS
2150
GISLGSPFHL
2160
TPDQEEKPFT
2170
SNKGPRILKP
2180
GEKSTLETKK
2190
IESESKGIKG
2200
GKKVYKSLIT
2210
GKVRSNSEIS
2220
GQMKQPLQAN
2230
MPSISRGRTM
2240
IHIPGVRNSS
2250
SSTSPVSKKG
2260
PPLKTPASKS
2270
PSEGQTATTS
2280
PRGAKPSVKS
2290
ELSPVARQTS
2300
QIGGSSKAPS
2310
RSGSRDSTPS
2320
RPAQQPLSRP
2330
IQSPGRNSIS
2340
PGRNGISPPN
2350
KLSQLPRTSS
2360
PSTASTKSSG
2370
SGKMSYTSPG
2380
RQMSQQNLTK
2390
QTGLSKNASS
2400
IPRSESASKG
2410
LNQMNNGNGA
2420
NKKVELSRMS
2430
STKSSGSESD
2440
RSERPVLVRQ
2450
STFIKEAPSP
2460
TLRRKLEESA
2470
SFESLSPSSR
2480
PASPTRSQAQ
2490
TPVLSPSLPD
2500
MSLSTHSSVQ
2510
AGGWRKLPPN
2520
LSPTIEYNDG
2530
RPAKRHDIAR
2540
SHSESPSRLP
2550
INRSGTWKRE
2560
HSKHSSSLPR
2570
VSTWRRTGSS
2580
SSILSASSES
2590
SEKAKSEDEK
2600
HVNSISGTKQ
2610
SKENQVSAKG
2620
TWRKIKENEF
2630
SPTNSTSQTV
2640
SSGATNGAES
2650
KTLIYQMAPA
2660
VSKTEDVWVR
2670
IEDCPINNPR
2680
SGRSPTGNTP
2690
PVIDSVSEKA
2700
NPNIKDSKDN
2710
QAKQNVGNGS
2720
VPMRTVGLEN
2730
RLNSFIQVDA
2740
PDQKGTEIKP
2750
GQNNPVPVSE
2760
TNESSIVERT
2770
PFSSSSSSKH
2780
SSPSGTVAAR
2790
VTPFNYNPSP
2800
RKSSADSTSA
2810
RPSQIPTPVN
2820
NNTKKRDSKT
2830
DSTESSGTQS
2840
PKRHSGSYLV
TSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Biological Process | GO:0001708 | cell fate specification |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0003203 | endocardial cushion morphogenesis |
| Biological Process | GO:0003170 | heart valve development |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:1902807 | negative regulation of cell cycle G1/S phase transition |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007389 | pattern specification process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:1904781 | positive regulation of protein localization to centrosome |
| Biological Process | GO:0031274 | positive regulation of pseudopodium assembly |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0060632 | regulation of microtubule-based movement |
| Biological Process | GO:0032886 | regulation of microtubule-based process |
| Biological Process | GO:0016055 | Wnt signaling pathway |
| Cellular Component | GO:0030877 | beta-catenin destruction complex |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0016342 | catenin complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:1990909 | Wnt signalosome |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0045295 | gamma-catenin binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019887 | protein kinase regulator activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0007155 | cell adhesion |
Reference
PMID: N/A