Search Results
Overview
| Uniprot ID | P25067 |
|---|---|
| Protein Name | Collagen alpha-2(VIII) chain |
| Gene Name | COL8A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 652 | TYTYDEYKKGYLDQA |
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity)
Protein Sequence
10
MLGTLTPLSS
20
LLLLLLVLVL
30
GCGPRASSGG
40
GAGGAAGYAP
50
VKYIQPMQKG
60
PVGPPFREGK
70
GQYLEMPLPL
80
LPMDLKGEPG
90
PPGKPGPRGP
100
PGPPGFPGKP
110
GMGKPGLHGQ
120
PGPAGPPGFS
130
RMGKAGPPGL
140
PGKVGPPGQP
150
GLRGEPGIRG
160
DQGLRGPPGP
170
PGLPGPSGIT
180
IPGKPGAQGV
190
PGPPGFQGEP
200
GPQGEPGPPG
210
DRGLKGDNGV
220
GQPGLPGAPG
230
QGGAPGPPGL
240
PGPAGLGKPG
250
LDGLPGAPGD
260
KGESGPPGVP
270
GPRGEPGAVG
280
PKGPPGVDGV
290
GVPGAAGLPG
300
PQGPSGAKGE
310
PGTRGPPGLI
320
GPTGYGMPGL
330
PGPKGDRGPA
340
GVPGLLGDRG
350
EPGEDGEPGE
360
QGPQGLGGPP
370
GLPGSAGLPG
380
RRGPPGPKGE
390
AGPGGPPGVP
400
GIRGDQGPSG
410
LAGKPGVPGE
420
RGLPGAHGPP
430
GPTGPKGEPG
440
FTGRPGGPGV
450
AGALGQKGDL
460
GLPGQPGLRG
470
PSGIPGLQGP
480
AGPIGPQGLP
490
GLKGEPGLPG
500
PPGEGRAGEP
510
GTAGPTGPPG
520
VPGSPGITGP
530
PGPPGPPGPP
540
GAPGAFDETG
550
IAGLHLPNGG
560
VEGAVLGKGG
570
KPQFGLGELS
580
AHATPAFTAV
590
LTSPFPASGM
600
PVKFDRTLYN
610
GHSGYNPATG
620
IFTCPVGGVY
630
YFAYHVHVKG
640
TNVWVALYKN
650
NVPATYTYDE
660
YKKGYLDQAS
670
GGAVLQLRPN
680
DQVWVQMPSD
690
QANGLYSTEY
700
IHSSFSGFLL
CPT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005591 | collagen type VIII trimer |
| Cellular Component | GO:0071953 | elastic fiber |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0030020 | extracellular matrix structural constituent conferring tensile strength |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0070831 | basement membrane assembly |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0030198 | extracellular matrix organization |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.