Search Results
Overview
| Uniprot ID | P25101 |
|---|---|
| Protein Name | Endothelin-1 receptor |
| Gene Name | EDNRA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 330 | HLSRILKKTVYNEMD |
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3
Protein Sequence
10
METLCLRASF
20
WLALVGCVIS
30
DNPERYSTNL
40
SNHVDDFTTF
50
RGTELSFLVT
60
THQPTNLVLP
70
SNGSMHNYCP
80
QQTKITSAFK
90
YINTVISCTI
100
FIVGMVGNAT
110
LLRIIYQNKC
120
MRNGPNALIA
130
SLALGDLIYV
140
VIDLPINVFK
150
LLAGRWPFDH
160
NDFGVFLCKL
170
FPFLQKSSVG
180
ITVLNLCALS
190
VDRYRAVASW
200
SRVQGIGIPL
210
VTAIEIVSIW
220
ILSFILAIPE
230
AIGFVMVPFE
240
YRGEQHKTCM
250
LNATSKFMEF
260
YQDVKDWWLF
270
GFYFCMPLVC
280
TAIFYTLMTC
290
EMLNRRNGSL
300
RIALSEHLKQ
310
RREVAKTVFC
320
LVVIFALCWF
330
PLHLSRILKK
340
TVYNEMDKNR
350
CELLSFLLLM
360
DYIGINLATM
370
NSCINPIALY
380
FVSKKFKNCF
390
QSCLCCCCYQ
400
SKSLMTSVPM
410
NGTSIQWKNH
420
DQNNHNTDRS
SHKDSMN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004962 | endothelin receptor activity |
| Molecular Function | GO:0004435 | phosphatidylinositol-4,5-bisphosphate phospholipase C activity |
| Biological Process | GO:0007190 | activation of adenylate cyclase activity |
| Biological Process | GO:0035904 | aorta development |
| Biological Process | GO:0014824 | artery smooth muscle contraction |
| Biological Process | GO:0003228 | atrial cardiac muscle tissue development |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0060385 | axonogenesis involved in innervation |
| Biological Process | GO:0001974 | blood vessel remodeling |
| Biological Process | GO:0001569 | branching involved in blood vessel morphogenesis |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0060070 | canonical Wnt signaling pathway |
| Biological Process | GO:0003207 | cardiac chamber formation |
| Biological Process | GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| Biological Process | GO:0044751 | cellular response to human chorionic gonadotropin stimulus |
| Biological Process | GO:0071373 | cellular response to luteinizing hormone stimulus |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0097237 | cellular response to toxic substance |
| Biological Process | GO:1904888 | cranial skeletal system development |
| Biological Process | GO:0048066 | developmental pigmentation |
| Biological Process | GO:0035050 | embryonic heart tube development |
| Biological Process | GO:0048706 | embryonic skeletal system development |
| Biological Process | GO:0086100 | endothelin receptor signaling pathway |
| Biological Process | GO:0048484 | enteric nervous system development |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0060324 | face development |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0072011 | glomerular endothelium development |
| Biological Process | GO:0003094 | glomerular filtration |
| Biological Process | GO:0003015 | heart process |
| Biological Process | GO:0030202 | heparin proteoglycan metabolic process |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0003220 | left ventricular cardiac muscle tissue morphogenesis |
| Biological Process | GO:1903537 | meiotic cell cycle process involved in oocyte maturation |
| Biological Process | GO:0097152 | mesenchymal cell apoptotic process |
| Biological Process | GO:0042474 | middle ear morphogenesis |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0014034 | neural crest cell fate commitment |
| Biological Process | GO:0050905 | neuromuscular process |
| Biological Process | GO:0016322 | neuron remodeling |
| Biological Process | GO:0003357 | noradrenergic neuron differentiation |
| Biological Process | GO:0042415 | norepinephrine metabolic process |
| Biological Process | GO:0061626 | pharyngeal arch artery morphogenesis |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:1903210 | podocyte apoptotic process |
| Biological Process | GO:0072112 | podocyte differentiation |
| Biological Process | GO:2001259 | positive regulation of cation channel activity |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0071806 | protein transmembrane transport |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:1905871 | regulation of protein localization to cell leading edge |
| Biological Process | GO:0097018 | renal albumin absorption |
| Biological Process | GO:0070294 | renal sodium ion absorption |
| Biological Process | GO:0007585 | respiratory gaseous exchange by respiratory system |
| Biological Process | GO:1905144 | response to acetylcholine |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0006939 | smooth muscle contraction |
| Biological Process | GO:0055078 | sodium ion homeostasis |
| Biological Process | GO:0048485 | sympathetic nervous system development |
| Biological Process | GO:0097492 | sympathetic neuron axon guidance |
| Biological Process | GO:0030878 | thyroid gland development |
| Biological Process | GO:0097084 | vascular associated smooth muscle cell development |
| Biological Process | GO:0042310 | vasoconstriction |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.