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Overview

Uniprot IDP25113
Protein NamePhosphoglycerate mutase 1
Gene NamePgam1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
100 GGLTGLNKAETAAKH
106 NKAETAAKHGEAQVK
113 KHGEAQVKIWRRSYD
241 GDEETVRKAMEAVAA
251 EAVAAQGKVKK****
39 PAGHEEAKRGGQALR

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate

Protein Sequence

10 MAAYKLVLIR 20 HGESAWNLEN 30 RFSGWYDADL 40 SPAGHEEAKR 50 GGQALRDAGY 60 EFDICFTSVQ 70 KRAIRTLWTV 80 LDAIDQMWLP 90 VVRTWRLNER 100 HYGGLTGLNK 110 AETAAKHGEA 120 QVKIWRRSYD 130 VPPPPMEPDH 140 PFYSNISKDR 150 RYADLTEDQL 160 PSCESLKDTI 170 ARALPFWNEE 180 IVPQIKEGKR 190 VLIAAHGNSL 200 RGIVKHLEGL 210 SEEAIMELNL 220 PTGIPIVYEL 230 DKNLKPIKPM 240 QFLGDEETVR 250 KAMEAVAAQG KVKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990917 ooplasm
Cellular Component GO:0120083 rough endoplasmic reticulum cisterna
Molecular Function GO:0004082 bisphosphoglycerate mutase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0004619 phosphoglycerate mutase activity
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.