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Overview

Uniprot IDP25286
Protein NameV-type proton ATPase 116 kDa subunit a 1
Gene NameAtp6v0a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
119 NTNQEALKRNFLELT
235 QLKNRVKKICEGFRA
255 PETPQERKEMASGVN
288 RVLQAAAKNIRVWFI
50 DVNVFQRKFVNEVRR
667 RHQYLRKKHLGTLNF

Function

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:32165585). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (By similarity)

Protein Sequence

10 MGELFRSEEM 20 TLAQLFLQSE 30 AAYCCVSELE 40 ELGKVQFRDL 50 NPDVNVFQRK 60 FVNEVRRCEE 70 MDRKLRFVEK 80 EIRKANIPIM 90 DTGENPEVPF 100 PRDMIDLEAN 110 FEKIENELKE 120 INTNQEALKR 130 NFLELTELKF 140 ILRKTQQFFD 150 EMADPDLLEE 160 SSSLLEPNEM 170 GRGAPLRLGF 180 VAGVINRERI 190 PTFERMLWRV 200 CRGNVFLRQA 210 EIENPLEDPV 220 TGDYVHKSVF 230 IIFFQGDQLK 240 NRVKKICEGF 250 RASLYPCPET 260 PQERKEMASG 270 VNTRIDDLQM 280 VLNQTEDHRQ 290 RVLQAAAKNI 300 RVWFIKVRKM 310 KAIYHTLNLC 320 NIDVTQKCLI 330 AEVWCPVTDL 340 DSIQFALRRG 350 TEHSGSTVPS 360 ILNRMQTNQT 370 PPTYNKTNKF 380 THGFQNIVDA 390 YGIGTYREIN 400 PAPYTVITFP 410 FLFAVMFGDF 420 GHGILMTLFA 430 VWMVLRESRI 440 LSQKNENEMF 450 SMVFSGRYII 460 LLMGLFSIYT 470 GLIYNDCFSK 480 SLNIFGSSWS 490 VRPMFTIGNW 500 TEETLLGSSV 510 LQLNPAIPGV 520 FGGPYPFGID 530 PIWNIATNKL 540 TFLNSFKMKM 550 SVILGIIHML 560 FGVSLSLFNH 570 IYFKKPLNIY 580 FGFIPEIIFM 590 SSLFGYLVIL 600 IFYKWTAYDA 610 HSSRNAPSLL 620 IHFINMFLFS 630 YPESGNAMLY 640 SGQKGIQCFL 650 IVVAMLCVPW 660 MLLFKPLILR 670 HQYLRKKHLG 680 TLNFGGIRVG 690 NGPTEEDAEI 700 IQHDQLSTHS 710 EDAEEPTEDE 720 VFDFGDTMVH 730 QAIHTIEYCL 740 GCISNTASYL 750 RLWALSLAHA 760 QLSEVLWTMV 770 IHIGLHVRSL 780 AGGLGLFFIF 790 AAFATLTVAI 800 LLIMEGLSAF 810 LHALRLHWVE 820 FQNKFYTGTG 830 FKFLPFSFEH IREGKFDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0097401 synaptic vesicle lumen acidification
Biological Process GO:0007035 vacuolar acidification
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0043195 terminal bouton
Cellular Component GO:0016471 vacuolar proton-transporting V-type ATPase complex
Cellular Component GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.