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Overview

Uniprot IDP25325
Protein Name3-mercaptopyruvate sulfurtransferase
Gene NameMPST
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
146 NLPLSSGKSQPAPAE
170 IKTYEDIKENLESRR
236 IRHLFQEKKVDLSKP

Function

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions

Protein Sequence

10 MASPQLCRAL 20 VSAQWVAEAL 30 RAPRAGQPLQ 40 LLDASWYLPK 50 LGRDARREFE 60 ERHIPGAAFF 70 DIDQCSDRTS 80 PYDHMLPGAE 90 HFAEYAGRLG 100 VGAATHVVIY 110 DASDQGLYSA 120 PRVWWMFRAF 130 GHHAVSLLDG 140 GLRHWLRQNL 150 PLSSGKSQPA 160 PAEFRAQLDP 170 AFIKTYEDIK 180 ENLESRRFQV 190 VDSRATGRFR 200 GTEPEPRDGI 210 EPGHIPGTVN 220 IPFTDFLSQE 230 GLEKSPEEIR 240 HLFQEKKVDL 250 SKPLVATCGS 260 GVTACHVALG 270 AYLCGKPDVP 280 IYDGSWVEWY 290 MRARPEDVIS EGRGKTH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0045202 synapse
Molecular Function GO:0016784 3-mercaptopyruvate sulfurtransferase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0016783 sulfurtransferase activity
Molecular Function GO:0004792 thiosulfate-cyanide sulfurtransferase activity
Biological Process GO:0009440 cyanate catabolic process
Biological Process GO:0070814 hydrogen sulfide biosynthetic process
Biological Process GO:0001822 kidney development
Biological Process GO:0001889 liver development
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0021510 spinal cord development
Biological Process GO:0000098 sulfur amino acid catabolic process
Biological Process GO:0019346 transsulfuration
Biological Process GO:0002143 tRNA wobble position uridine thiolation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.