Search Results

Overview

Uniprot IDP25391
Protein NameLaminin subunit alpha-1
Gene NameLAMA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1618 QKDLGKIKLEGVAEE
1631 EETDNLQKKLTRMLA
1642 RMLASTQKVNRATER
1756 AASHVLSKHNNELKA
2012 RDKGAKTKELATSAS
679 RANYNSAKMALYRLE

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a ligand for alpha-dystroglycan, it is involved in a number of processes including epithelium branching morphogenesis, down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling, and activation of RAC1 signaling. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway

Protein Sequence

10 MRGGVLLVLL 20 LCVAAQCRQR 30 GLFPAILNLA 40 SNAHISTNAT 50 CGEKGPEMFC 60 KLVEHVPGRP 70 VRNPQCRICD 80 GNSANPRERH 90 PISHAIDGTN 100 NWWQSPSIQN 110 GREYHWVTIT 120 LDLRQVFQVA 130 YVIIKAANAP 140 RPGNWILERS 150 LDGTTFSPWQ 160 YYAVSDSECL 170 SRYNITPRRG 180 PPTYRADDEV 190 ICTSYYSRLV 200 PLEHGEIHTS 210 LINGRPSADD 220 LSPKLLEFTS 230 ARYIRLRLQR 240 IRTLNADLMT 250 LSHREPKELD 260 PIVTRRYYYS 270 IKDISVGGMC 280 ICYGHASSCP 290 WDETTKKLQC 300 QCEHNTCGES 310 CNRCCPGYHQ 320 QPWRPGTVSS 330 GNTCEACNCH 340 NKAKDCYYDE 350 SVAKQKKSLN 360 TAGQFRGGGV 370 CINCLQNTMG 380 INCETCIDGY 390 YRPHKVSPYE 400 DEPCRPCNCD 410 PVGSLSSVCI 420 KDDLHSDLHN 430 GKQPGQCPCK 440 EGYTGEKCDR 450 CQLGYKDYPT 460 CVSCGCNPVG 470 SASDEPCTGP 480 CVCKENVEGK 490 ACDRCKPGFY 500 NLKEKNPRGC 510 SECFCFGVSD 520 VCSSLSWPVG 530 QVNSMSGWLV 540 TDLISPRKIP 550 SQQDALGGRH 560 QVSINNTAVM 570 QRLAPKYYWA 580 APEAYLGNKL 590 TAFGGFLKYT 600 VSYDIPVETV 610 DSNLMSHADV 620 IIKGNGLTLS 630 TQAEGLSLQP 640 YEEYLNVVRL 650 VPENFQDFHS 660 KRQIDRDQLM 670 TVLANVTHLL 680 IRANYNSAKM 690 ALYRLESVSL 700 DIASSNAIDL 710 VVAADVEHCE 720 CPQGYTGTSC 730 ESCLSGYYRV 740 DGILFGGICQ 750 PCECHGHAAE 760 CNVHGVCIAC 770 AHNTTGVHCE 780 QCLPGFYGEP 790 SRGTPGDCQP 800 CACPLTIASN 810 NFSPTCHLND 820 GDEVVCDWCA 830 PGYSGAWCER 840 CADGYYGNPT 850 VPGESCVPCD 860 CSGNVDPSEA 870 GHCDSVTGEC 880 LKCLGNTDGA 890 HCERCADGFY 900 GDAVTAKNCR 910 ACECHVKGSH 920 SAVCHLETGL 930 CDCKPNVTGQ 940 QCDQCLHGYY 950 GLDSGHGCRP 960 CNCSVAGSVS 970 DGCTDEGQCH 980 CVPGVAGKRC 990 DRCAHGFYAY 1000 QDGSCTPCDC 1010 PHTQNTCDPE 1020 TGECVCPPHT 1030 QGVKCEECED 1040 GHWGYDAEVG 1050 CQACNCSLVG 1060 STHHRCDVVT 1070 GHCQCKSKFG 1080 GRACDQCSLG 1090 YRDFPDCVPC 1100 DCDLRGTSGD 1110 ACNLEQGLCG 1120 CVEETGACPC 1130 KENVFGPQCN 1140 ECREGTFALR 1150 ADNPLGCSPC 1160 FCSGLSHLCS 1170 ELEDYVRTPV 1180 TLGSDQPLLR 1190 VVSQSNLRGT 1200 TEGVYYQAPD 1210 FLLDAATVRQ 1220 HIRAEPFYWR 1230 LPQQFQGDQL 1240 MAYGGKLKYS 1250 VAFYSLDGVG 1260 TSNFEPQVLI 1270 KGGRIRKQVI 1280 YMDAPAPENG 1290 VRQEQEVAMR 1300 ENFWKYFNSV 1310 SEKPVTREDF 1320 MSVLSDIEYI 1330 LIKASYGQGL 1340 QQSRISDISM 1350 EVGRKAEKLH 1360 PEEEVASLLE 1370 NCVCPPGTVG 1380 FSCQDCAPGY 1390 HRGKLPAGSD 1400 RGPRPLVAPC 1410 VPCSCNNHSD 1420 TCDPNTGKCL 1430 NCGDNTAGDH 1440 CDVCTSGYYG 1450 KVTGSASDCA 1460 LCACPHSPPA 1470 SFSPTCVLEG 1480 DHDFRCDACL 1490 LGYEGKHCER 1500 CSSSYYGNPQ 1510 TPGGSCQKCD 1520 CNPHGSVHGD 1530 CDRTSGQCVC 1540 RLGASGLRCD 1550 ECEPRHILME 1560 TDCVSCDDEC 1570 VGVLLNDLDE 1580 IGDAVLSLNL 1590 TGIIPVPYGI 1600 LSNLENTTKY 1610 LQESLLKENM 1620 QKDLGKIKLE 1630 GVAEETDNLQ 1640 KKLTRMLAST 1650 QKVNRATERI 1660 FKESQDLAIA 1670 IERLQMSITE 1680 IMEKTTLNQT 1690 LDEDFLLPNS 1700 TLQNMQQNGT 1710 SLLEIMQIRD 1720 FTQLHQNATL 1730 ELKAAEDLLS 1740 QIQENYQKPL 1750 EELEVLKEAA 1760 SHVLSKHNNE 1770 LKAAEALVRE 1780 AEAKMQESNH 1790 LLLMVNANLR 1800 EFSDKKLHVQ 1810 EEQNLTSELI 1820 VQGRGLIDAA 1830 AAQTDAVQDA 1840 LEHLEDHQDK 1850 LLLWSAKIRH 1860 HIDDLVMHMS 1870 QRNAVDLVYR 1880 AEDHAAEFQR 1890 LADVLYSGLE 1900 NIRNVSLNAT 1910 SAAYVHYNIQ 1920 SLIEESEELA 1930 RDAHRTVTET 1940 SLLSESLVSN 1950 GKAAVQRSSR 1960 FLKEGNNLSR 1970 KLPGIALELS 1980 ELRNKTNRFQ 1990 ENAVEITRQT 2000 NESLLILRAI 2010 PKGIRDKGAK 2020 TKELATSASQ 2030 SAVSTLRDVA 2040 GLSQELLNTS 2050 ASLSRVNTTL 2060 RETHQLLQDS 2070 TMATLLAGRK 2080 VKDVEIQANL 2090 LFDRLKPLKM 2100 LEENLSRNLS 2110 EIKLLISQAR 2120 KQAASIKVAV 2130 SADRDCIRAY 2140 QPQISSTNYN 2150 TLTLNVKTQE 2160 PDNLLFYLGS 2170 STASDFLAVE 2180 MRRGRVAFLW 2190 DLGSGSTRLE 2200 FPDFPIDDNR 2210 WHSIHVARFG 2220 NIGSLSVKEM 2230 SSNQKSPTKT 2240 SKSPGTANVL 2250 DVNNSTLMFV 2260 GGLGGQIKKS 2270 PAVKVTHFKG 2280 CLGEAFLNGK 2290 SIGLWNYIER 2300 EGKCRGCFGS 2310 SQNEDPSFHF 2320 DGSGYSVVEK 2330 SLPATVTQII 2340 MLFNTFSPNG 2350 LLLYLGSYGT 2360 KDFLSIELFR 2370 GRVKVMTDLG 2380 SGPITLLTDR 2390 RYNNGTWYKI 2400 AFQRNRKQGV 2410 LAVIDAYNTS 2420 NKETKQGETP 2430 GASSDLNRLD 2440 KDPIYVGGLP 2450 RSRVVRRGVT 2460 TKSFVGCIKN 2470 LEISRSTFDL 2480 LRNSYGVRKG 2490 CLLEPIRSVS 2500 FLKGGYIELP 2510 PKSLSPESEW 2520 LVTFATTNSS 2530 GIILAALGGD 2540 VEKRGDREEA 2550 HVPFFSVMLI 2560 GGNIEVHVNP 2570 GDGTGLRKAL 2580 LHAPTGTCSD 2590 GQAHSISLVR 2600 NRRIITVQLD 2610 ENNPVEMKLG 2620 TLVESRTINV 2630 SNLYVGGIPE 2640 GEGTSLLTMR 2650 RSFHGCIKNL 2660 IFNLELLDFN 2670 SAVGHEQVDL 2680 DTCWLSERPK 2690 LAPDAEDSKL 2700 LPEPRAFPEQ 2710 CVVDAALEYV 2720 PGAHQFGLTQ 2730 NSHFILPFNQ 2740 SAVRKKLSVE 2750 LSIRTFASSG 2760 LIYYMAHQNQ 2770 ADYAVLQLHG 2780 GRLHFMFDLG 2790 KGRTKVSHPA 2800 LLSDGKWHTV 2810 KTDYVKRKGF 2820 ITVDGRESPM 2830 VTVVGDGTML 2840 DVEGLFYLGG 2850 LPSQYQARKI 2860 GNITHSIPAC 2870 IGDVTVNSKQ 2880 LDKDSPVSAF 2890 TVNRCYAVAQ 2900 EGTYFDGSGY 2910 AALVKEGYKV 2920 QSDVNITLEF 2930 RTSSQNGVLL 2940 GISTAKVDAI 2950 GLELVDGKVL 2960 FHVNNGAGRI 2970 TAAYEPKTAT 2980 VLCDGKWHTL 2990 QANKSKHRIT 3000 LIVDGNAVGA 3010 ESPHTQSTSV 3020 DTNNPIYVGG 3030 YPAGVKQKCL 3040 RSQTSFRGCL 3050 RKLALIKSPQ 3060 VQSFDFSRAF 3070 ELHGVFLHSC PGTES

Gene Ontology

Classification GO ID Description
Biological Process GO:0010656 negative regulation of muscle cell apoptotic process
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005606 laminin-111 trimer
Cellular Component GO:0005608 laminin-121 trimer
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0043208 glycosphingolipid binding
Molecular Function GO:0048018 receptor ligand activity
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0035022 positive regulation of Rac protein signal transduction
Biological Process GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
Biological Process GO:0110011 regulation of basement membrane organization
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.