Search Results
Overview
| Uniprot ID | P25685 |
|---|---|
| Protein Name | DnaJ homolog subfamily B member 1 |
| Gene Name | DNAJB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | AQEPARKKQDPPVTH |
| 181 | EIYSGCTKKMKISHK |
| 195 | KRLNPDGKSIRNEDK |
Function
Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region (PubMed:14503850). Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0061827 | sperm head |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0030900 | forebrain development |
| Biological Process | GO:0090084 | negative regulation of inclusion body assembly |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1903334 | positive regulation of protein folding |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:1900034 | regulation of cellular response to heat |
| Biological Process | GO:0006986 | response to unfolded protein |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.