Search Results
Overview
| Uniprot ID | P25815 |
|---|---|
| Protein Name | Protein S100-P |
| Gene Name | S100P |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 30 | GSTQTLTKGELKVLM |
| 34 | TLTKGELKVLMEKEL |
| 39 | ELKVLMEKELPGFLQ |
| 49 | PGFLQSGKDKDAVDK |
| 56 | KDKDAVDKLLKDLDA |
Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE)
Protein Sequence
10
MTELETAMGM
20
IIDVFSRYSG
30
SEGSTQTLTK
40
GELKVLMEKE
50
LPGFLQSGKD
60
KDAVDKLLKD
70
LDANGDAQVD
80
FSEFIVFVAA
90
ITSACHKYFE
KAGLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0031528 | microvillus membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0043542 | endothelial cell migration |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.