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Overview

Uniprot IDP25874
Protein NameMitochondrial brown fat uncoupling protein 1
Gene NameUCP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
73 VKTEGRMKLYSGLPA

Function

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960, PubMed:28781081). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity)

Protein Sequence

10 MGGLTASDVH 20 PTLGVQLFSA 30 GIAACLADVI 40 TFPLDTAKVR 50 LQVQGECPTS 60 SVIRYKGVLG 70 TITAVVKTEG 80 RMKLYSGLPA 90 GLQRQISSAS 100 LRIGLYDTVQ 110 EFLTAGKETA 120 PSLGSKILAG 130 LTTGGVAVFI 140 GQPTEVVKVR 150 LQAQSHLHGI 160 KPRYTGTYNA 170 YRIIATTEGL 180 TGLWKGTTPN 190 LMRSVIINCT 200 ELVTYDLMKE 210 AFVKNNILAD 220 DVPCHLVSAL 230 IAGFCATAMS 240 SPVDVVKTRF 250 INSPPGQYKS 260 VPNCAMKVFT 270 NEGPTAFFKG 280 LVPSFLRLGS 290 WNVIMFVCFE 300 QLKRELSKSR QTMDCAT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:1901612 cardiolipin binding
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0036041 long-chain fatty acid binding
Molecular Function GO:0017077 oxidative phosphorylation uncoupler activity
Molecular Function GO:0015078 proton transmembrane transporter activity
Molecular Function GO:0032555 purine ribonucleotide binding
Molecular Function GO:0022857 transmembrane transporter activity
Biological Process GO:1990845 adaptive thermogenesis
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:0070417 cellular response to cold
Biological Process GO:1903495 cellular response to dehydroepiandrosterone
Biological Process GO:0071398 cellular response to fatty acid
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0002024 diet induced thermogenesis
Biological Process GO:1990542 mitochondrial transmembrane transport
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:1903426 regulation of reactive oxygen species biosynthetic process
Biological Process GO:0009409 response to cold
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0009266 response to temperature stimulus

Reference

PMID: N/A