Search Results
Overview
| Uniprot ID | P26006 |
|---|---|
| Protein Name | Integrin alpha-3 |
| Gene Name | ITGA3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1031 | TRALYEAKRQKAEMK |
| 407 | YIYHSSSKGLLRQPQ |
| 620 | KECGPDNKCESNLQM |
| 638 | FVSEQQQKLSRLQYS |
| 897 | LAAAKKAKSETVLTC |
Function
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration
Protein Sequence
10
MGPGPSRAPR
20
APRLMLCALA
30
LMVAAGGCVV
40
SAFNLDTRFL
50
VVKEAGNPGS
60
LFGYSVALHR
70
QTERQQRYLL
80
LAGAPRELAV
90
PDGYTNRTGA
100
VYLCPLTAHK
110
DDCERMNITV
120
KNDPGHHIIE
130
DMWLGVTVAS
140
QGPAGRVLVC
150
AHRYTQVLWS
160
GSEDQRRMVG
170
KCYVRGNDLE
180
LDSSDDWQTY
190
HNEMCNSNTD
200
YLETGMCQLG
210
TSGGFTQNTV
220
YFGAPGAYNW
230
KGNSYMIQRK
240
EWDLSEYSYK
250
DPEDQGNLYI
260
GYTMQVGSFI
270
LHPKNITIVT
280
GAPRHRHMGA
290
VFLLSQEAGG
300
DLRRRQVLEG
310
SQVGAYFGSA
320
IALADLNNDG
330
WQDLLVGAPY
340
YFERKEEVGG
350
AIYVFMNQAG
360
TSFPAHPSLL
370
LHGPSGSAFG
380
LSVASIGDIN
390
QDGFQDIAVG
400
APFEGLGKVY
410
IYHSSSKGLL
420
RQPQQVIHGE
430
KLGLPGLATF
440
GYSLSGQMDV
450
DENFYPDLLV
460
GSLSDHIVLL
470
RARPVINIVH
480
KTLVPRPAVL
490
DPALCTATSC
500
VQVELCFAYN
510
QSAGNPNYRR
520
NITLAYTLEA
530
DRDRRPPRLR
540
FAGSESAVFH
550
GFFSMPEMRC
560
QKLELLLMDN
570
LRDKLRPIII
580
SMNYSLPLRM
590
PDRPRLGLRS
600
LDAYPILNQA
610
QALENHTEVQ
620
FQKECGPDNK
630
CESNLQMRAA
640
FVSEQQQKLS
650
RLQYSRDVRK
660
LLLSINVTNT
670
RTSERSGEDA
680
HEALLTLVVP
690
PALLLSSVRP
700
PGACQANETI
710
FCELGNPFKR
720
NQRMELLIAF
730
EVIGVTLHTR
740
DLQVQLQLST
750
SSHQDNLWPM
760
ILTLLVDYTL
770
QTSLSMVNHR
780
LQSFFGGTVM
790
GESGMKTVED
800
VGSPLKYEFQ
810
VGPMGEGLVG
820
LGTLVLGLEW
830
PYEVSNGKWL
840
LYPTEITVHG
850
NGSWPCRPPG
860
DLINPLNLTL
870
SDPGDRPSSP
880
QRRRRQLDPG
890
GGQGPPPVTL
900
AAAKKAKSET
910
VLTCATGRAH
920
CVWLECPIPD
930
APVVTNVTVK
940
ARVWNSTFIE
950
DYRDFDRVRV
960
NGWATLFLRT
970
SIPTINMENK
980
TTWFSVDIDS
990
ELVEELPAEI
1000
ELWLVLVAVG
1010
AGLLLLGLII
1020
LLLWKCGFFK
1030
RARTRALYEA
1040
KRQKAEMKSQ
1050
PSETERLTDD
Y
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Biological Process | GO:0099560 | synaptic membrane adhesion |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0034667 | integrin alpha3-beta1 complex |
| Cellular Component | GO:0008305 | integrin complex |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0043235 | receptor complex |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0097062 | dendritic spine maintenance |
| Biological Process | GO:0035640 | exploration behavior |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0048333 | mesodermal cell differentiation |
| Biological Process | GO:0035024 | negative regulation of Rho protein signal transduction |
| Biological Process | GO:0072006 | nephron development |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0030510 | regulation of BMP signaling pathway |
| Biological Process | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0030111 | regulation of Wnt signaling pathway |
| Biological Process | GO:0097205 | renal filtration |
| Biological Process | GO:0043588 | skin development |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.