Overview
| Uniprot ID | P26041 |
|---|
| Protein Name | Moesin |
|---|
| Gene Name | Msn |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 262 |
FVIKPIDKKAPDFVF |
| 263 |
VIKPIDKKAPDFVFY |
Function
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (By similarity). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (By similarity). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (By similarity). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:22875842). Modulates phagolysosomal biogenesis in macrophages (PubMed:28978692). Also participates in immunologic synapse formation (By similarity)
Protein Sequence
10
MPKTISVRVT
20
TMDAELEFAI
30
QPNTTGKQLF
40
DQVVKTIGLR
50
EVWFFGLQYQ
60
DTKAFSTWLK
70
LNKKVTAQDV
80
RKESPLLFKF
90
RAKFYPEDVS
100
EELIQDITQR
110
LFFLQVKEGI
120
LNDDIYCPPE
130
TAVLLASYAV
140
QSKYGDFNKE
150
VHKSGYLAGD
160
KLLPQRVLEQ
170
HKLNKDQWEE
180
RIQVWHEEHR
190
GMLREDAVLE
200
YLKIAQDLEM
210
YGVNYFSIKN
220
KKGSELWLGV
230
DALGLNIYEQ
240
NDRLTPKIGF
250
PWSEIRNISF
260
NDKKFVIKPI
270
DKKAPDFVFY
280
APRLRINKRI
290
LALCMGNHEL
300
YMRRRKPDTI
310
EVQQMKAQAR
320
EEKHQKQMER
330
ALLENEKKKR
340
ELAEKEKEKI
350
EREKEELMEK
360
LKQIEEQTKK
370
AQQELEEQTR
380
RALELEQERK
390
RAQSEAEKLA
400
KERQEAEEAK
410
EALLQASRDQ
420
KKTQEQLASE
430
MAELTARISQ
440
LEMARKKKES
450
EAVEWQQKAQ
460
MVQEDLEKTR
470
AELKTAMSTP
480
HVAEPAENEH
490
DEQDENGAEA
500
SAELRADAMA
510
KDRSEEERTT
520
EAEKNERVQK
530
HLKALTSELA
540
NARDESKKTA
550
NDMIHAENMR
560
LGRDKYKTLR
570
QIRQGNTKQR
IDEFESM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Biological Process |
GO:1902115 |
regulation of organelle assembly |
| Biological Process |
GO:0070489 |
T cell aggregation |
| Biological Process |
GO:0072678 |
T cell migration |
| Biological Process |
GO:0042098 |
T cell proliferation |
| Cellular Component |
GO:0045177 |
apical part of cell |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0009898 |
cytoplasmic side of plasma membrane |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0031527 |
filopodium membrane |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005902 |
microvillus |
| Cellular Component |
GO:0031528 |
microvillus membrane |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0031143 |
pseudopodium |
| Cellular Component |
GO:0030315 |
T-tubule |
| Cellular Component |
GO:0001931 |
uropod |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0050839 |
cell adhesion molecule binding |
| Molecular Function |
GO:0003725 |
double-stranded RNA binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0061028 |
establishment of endothelial barrier |
| Biological Process |
GO:0045198 |
establishment of epithelial cell apical/basal polarity |
| Biological Process |
GO:0022612 |
gland morphogenesis |
| Biological Process |
GO:0001771 |
immunological synapse formation |
| Biological Process |
GO:0022614 |
membrane to membrane docking |
| Biological Process |
GO:2000643 |
positive regulation of early endosome to late endosome transport |
| Biological Process |
GO:0010628 |
positive regulation of gene expression |
| Biological Process |
GO:0071803 |
positive regulation of podosome assembly |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:1902966 |
positive regulation of protein localization to early endosome |
| Biological Process |
GO:0008360 |
regulation of cell shape |
| Biological Process |
GO:0008361 |
regulation of cell size |
| Biological Process |
GO:2000401 |
regulation of lymphocyte migration |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.