Overview
| Uniprot ID | P26196 |
|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX6 |
|---|
| Gene Name | DDX6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 81 |
KTLKLPPKDLRIKTS |
Function
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)
Protein Sequence
10
MSTARTENPV
20
IMGLSSQNGQ
30
LRGPVKPTGG
40
PGGGGTQTQQ
50
QMNQLKNTNT
60
INNGTQQQAQ
70
SMTTTIKPGD
80
DWKKTLKLPP
90
KDLRIKTSDV
100
TSTKGNEFED
110
YCLKRELLMG
120
IFEMGWEKPS
130
PIQEESIPIA
140
LSGRDILARA
150
KNGTGKSGAY
160
LIPLLERLDL
170
KKDNIQAMVI
180
VPTRELALQV
190
SQICIQVSKH
200
MGGAKVMATT
210
GGTNLRDDIM
220
RLDDTVHVVI
230
ATPGRILDLI
240
KKGVAKVDHV
250
QMIVLDEADK
260
LLSQDFVQIM
270
EDIILTLPKN
280
RQILLYSATF
290
PLSVQKFMNS
300
HLQKPYEINL
310
MEELTLKGVT
320
QYYAYVTERQ
330
KVHCLNTLFS
340
RLQINQSIIF
350
CNSSQRVELL
360
AKKISQLGYS
370
CFYIHAKMRQ
380
EHRNRVFHDF
390
RNGLCRNLVC
400
TDLFTRGIDI
410
QAVNVVINFD
420
FPKLAETYLH
430
RIGRSGRFGH
440
LGLAINLITY
450
DDRFNLKSIE
460
EQLGTEIKPI
470
PSNIDKSLYV
480
AEYHSEPVED
EKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0016442 |
RISC complex |
| Cellular Component |
GO:0097227 |
sperm annulus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0004386 |
helicase activity |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003724 |
RNA helicase activity |
| Biological Process |
GO:0000290 |
deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Biological Process |
GO:0035278 |
miRNA-mediated gene silencing by inhibition of translation |
| Biological Process |
GO:0017148 |
negative regulation of translation |
| Biological Process |
GO:0000288 |
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process |
GO:0033962 |
P-body assembly |
| Biological Process |
GO:1990261 |
pre-mRNA catabolic process |
| Biological Process |
GO:0048515 |
spermatid differentiation |
| Biological Process |
GO:0034063 |
stress granule assembly |
| Biological Process |
GO:0019074 |
viral RNA genome packaging |
| Cellular Component |
GO:0033391 |
chromatoid body |
| Cellular Component |
GO:0061830 |
concave side of sperm head |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000792 |
heterochromatin |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0001520 |
outer dense fiber |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.