Overview
| Uniprot ID | P26231 |
|---|
| Protein Name | Catenin alpha-1 |
|---|
| Gene Name | Ctnna1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 842 |
ASYVASTKYQKSQGM |
Function
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). May play a crucial role in cell differentiation
Protein Sequence
10
MTAVHAGNIN
20
FKWDPKSLEI
30
RTLAVERLLE
40
PLVTQVTTLV
50
NTNSKGPSNK
60
KRGRSKKAHV
70
LAASVEQATE
80
NFLEKGDKIA
90
KESQFLKEEL
100
VVAVEDVRKQ
110
GDLMKSAAGE
120
FADDPCSSVK
130
RGNMVRAARA
140
LLSAVTRLLI
150
LADMADVYKL
160
LVQLKVVEDG
170
ILKLRNAGNE
180
QDLGIQYKAL
190
KPEVDKLNIM
200
AAKRQQELKD
210
VGNRDQMAAA
220
RGILQKNVPI
230
LYTASQACLQ
240
HPDVAAYKAN
250
RDLIYKQLQQ
260
AVTGISNAAQ
270
ATASDDAAQH
280
QGGSGGELAY
290
ALNNFDKQII
300
VDPLSFSEER
310
FRPSLEERLE
320
SIISGAALMA
330
DSSCTRDDRR
340
ERIVAECNAV
350
RQALQDLLSE
360
YMGNAGRKER
370
SDALNSAIDK
380
MTKKTRDLRR
390
QLRKAVMDHV
400
SDSFLETNVP
410
LLVLIEAAKN
420
GNEKEVKEYA
430
QVFREHANKL
440
IEVANLACSI
450
SNNEEGVKLV
460
RMSASQLEAL
470
CPQVINAALA
480
LAAKPQSKLA
490
QENMDLFKEQ
500
WEKQVRVLTD
510
AVDDITSIDD
520
FLAVSENHIL
530
EDVNKCVIAL
540
QEKDVDGLDR
550
TAGAIRGRAA
560
RVIHVVTSEM
570
DNYEPGVYTE
580
KVLEATKLLS
590
NTVMPRFTEQ
600
VEAAVEALSS
610
DPAQPMDENE
620
FIDASRLVYD
630
GIRDIRKAVL
640
MIRTPEELDD
650
SDFETEDFDV
660
RSRTSVQTED
670
DQLIAGQSAR
680
AIMAQLPQEQ
690
KAKIAEQVAS
700
FQEEKSKLDA
710
EVSKWDDSGN
720
DIIVLAKQMC
730
MIMMEMTDFT
740
RGKGPLKNTS
750
DVISAAKKIA
760
EAGSRMDKLG
770
RTIADHCPDS
780
ACKQDLLAYL
790
QRIALYCHQL
800
NICSKVKAEV
810
QNLGGELVVS
820
GVDSAMSLIQ
830
AAKNLMNAVV
840
QTVKASYVAS
850
TKYQKSQGMA
860
SLNLPAVSWK
870
MKAPEKKPLV
880
KREKQDETQT
890
KIKRASQKKH
900
VNPVQALSEF
KAMDSI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001669 |
acrosomal vesicle |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0016342 |
catenin complex |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0016600 |
flotillin complex |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0120212 |
sperm head-tail coupling apparatus |
| Cellular Component |
GO:0097225 |
sperm midpiece |
| Cellular Component |
GO:0097228 |
sperm principal piece |
| Cellular Component |
GO:0005915 |
zonula adherens |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0045295 |
gamma-catenin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Molecular Function |
GO:0017166 |
vinculin binding |
| Biological Process |
GO:0043297 |
apical junction assembly |
| Biological Process |
GO:0031103 |
axon regeneration |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0071681 |
cellular response to indole-3-methanol |
| Biological Process |
GO:0090136 |
epithelial cell-cell adhesion |
| Biological Process |
GO:0007163 |
establishment or maintenance of cell polarity |
| Biological Process |
GO:0016264 |
gap junction assembly |
| Biological Process |
GO:0008104 |
intracellular protein localization |
| Biological Process |
GO:0008584 |
male gonad development |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:2000146 |
negative regulation of cell motility |
| Biological Process |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| Biological Process |
GO:2001045 |
negative regulation of integrin-mediated signaling pathway |
| Biological Process |
GO:0007406 |
negative regulation of neuroblast proliferation |
| Biological Process |
GO:1900181 |
negative regulation of protein localization to nucleus |
| Biological Process |
GO:0042475 |
odontogenesis of dentin-containing tooth |
| Biological Process |
GO:0001541 |
ovarian follicle development |
| Biological Process |
GO:2001241 |
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| Biological Process |
GO:0045880 |
positive regulation of smoothened signaling pathway |
| Biological Process |
GO:0042127 |
regulation of cell population proliferation |
| Biological Process |
GO:0043627 |
response to estrogen |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.