Search Results
Overview
| Uniprot ID | P26234 |
|---|---|
| Protein Name | Vinculin |
| Gene Name | VCL |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1021 | RALIQCAKDIAKASD |
| 1025 | QCAKDIAKASDEVTR |
| 1035 | DEVTRLAKEVAKQCT |
| 1039 | RLAKEVAKQCTDKRI |
| 1071 | LKILSTVKATMLGRT |
| 1116 | EAEAASIKIRTDAGF |
| 216 | MKIFVTTKNSKNQGI |
| 219 | FVTTKNSKNQGIEEA |
| 228 | QGIEEALKNRNFTVE |
| 277 | ALASIDSKLNQAKGW |
| 282 | DSKLNQAKGWLRDPT |
| 309 | QILDEAGKVGELCAG |
| 317 | VGELCAGKERREILG |
| 418 | GALAEARKIAELCDD |
| 427 | AELCDDPKERDDILR |
| 465 | PEARALAKQVATALQ |
| 477 | ALQNLQTKTNRAVAN |
| 489 | VANSRPAKAAVHLEG |
| 497 | AAVHLEGKIEQAQRW |
| 59 | SNLVRVGKETVQTTE |
| 647 | RLGATAEKAAAVGTA |
| 656 | AAVGTANKSTVEGIQ |
| 667 | EGIQASVKTARELTP |
| 71 | TTEDQILKRDMPPAF |
| 732 | DASEEAIKKDLDKCK |
| 779 | VENSEDPKFREAVKA |
| 785 | PKFREAVKAASDELS |
| 831 | RILGAVAKVREAFQP |
| 984 | EATKWSSKGNDIIAA |
| 993 | NDIIAAAKRMALLMA |
Function
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion
Protein Sequence
10
MPVFHTRTIE
20
SILEPVAQQI
30
SHLVIMHEEG
40
EVDGKAIPDL
50
TAPVAAVQAA
60
VSNLVRVGKE
70
TVQTTEDQIL
80
KRDMPPAFIK
90
VENACTKLVQ
100
AAQMLQSDPY
110
SVPARDYLID
120
GSRGILSGTS
130
DLLLTFDEAE
140
VRKIIRVCKG
150
ILEYLTVAEV
160
VETMEDLVTY
170
TKNLGPGMTK
180
MAKMIDERQQ
190
ELTHQEHRVM
200
LVNSMNTVKE
210
LLPVLISAMK
220
IFVTTKNSKN
230
QGIEEALKNR
240
NFTVEKMSAE
250
INEIIRVLQL
260
TSWDEDAWAS
270
KKDTEAMKRA
280
LASIDSKLNQ
290
AKGWLRDPTA
300
SPGDAGEQAI
310
RQILDEAGKV
320
GELCAGKERR
330
EILGTCKMLG
340
QMTDQVADLR
350
ARGQGASPVA
360
MQKAQQVSQG
370
LDVLTAKVEN
380
AARKLEAMTN
390
SKQSIAKKID
400
AAQNWLADPN
410
GGPEGEEQIR
420
GALAEARKIA
430
ELCDDPKERD
440
DILRSLGEIS
450
ALTSKLADLR
460
RQGKGDSPEA
470
RALAKQVATA
480
LQNLQTKTNR
490
AVANSRPAKA
500
AVHLEGKIEQ
510
AQRWIDNPTV
520
DDRGVGQAAI
530
RGLVAEGHRL
540
ANVMMGPYRQ
550
DLLAKCDRVD
560
QLTAQLADLA
570
ARGEGESPQA
580
RALASQLQDS
590
LKDLKARMQE
600
AMTQEVSDVF
610
SDTTTPIKLL
620
AVAATAPPDA
630
PNREEVFDER
640
AANFENHSGR
650
LGATAEKAAA
660
VGTANKSTVE
670
GIQASVKTAR
680
ELTPQVVSAA
690
RILLRNPGNQ
700
AAYEHFETMK
710
NQWIDNVEKM
720
TGLVDEAIDT
730
KSLLDASEEA
740
IKKDLDKCKV
750
AMANIQPQML
760
VAGATSIARR
770
ANRILLVAKR
780
EVENSEDPKF
790
REAVKAASDE
800
LSKTISPMVM
810
DAKAVAGNIS
820
DPGLQKSFLD
830
SGYRILGAVA
840
KVREAFQPQE
850
PDFPPPPPDL
860
EQLRLTDELA
870
PPKPPLPEGE
880
VPPPRPPPPE
890
EKDEEFPEQK
900
AGEVINQPMM
910
MAARQLHDEA
920
RKWSSKPGNP
930
AAKVGIGVVA
940
EADAADAVGF
950
PVPSDMEDDY
960
EPELLLMPSS
970
QPVNQPILAA
980
AQSLHREATK
990
WSSKGNDIIA
1000
AAKRMALLMA
1010
EMSRLVRGGS
1020
GTKRALIQCA
1030
KDIAKASDEV
1040
TRLAKEVAKQ
1050
CTDKRIRTNL
1060
LQVCERIPTI
1070
STQLKILSTV
1080
KATMLGRTNI
1090
SDEESEQATE
1100
MLVHNAQNLM
1110
QSVKETVREA
1120
EAASIKIRTD
1130
AGFTLRWVRK
TPWYQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0043034 | costamere |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005916 | fascia adherens |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0090637 | inner dense plaque of desmosome |
| Cellular Component | GO:0090636 | outer dense plaque of desmosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0061826 | podosome ring |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:1990357 | terminal web |
| Cellular Component | GO:0005915 | zonula adherens |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0045294 | alpha-catenin binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034333 | adherens junction assembly |
| Biological Process | GO:0043297 | apical junction assembly |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0090136 | epithelial cell-cell adhesion |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0002009 | morphogenesis of an epithelium |
| Biological Process | GO:0034394 | protein localization to cell surface |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
| Biological Process | GO:1904702 | regulation of protein localization to adherens junction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.