Search Results

Overview

Uniprot ID	P26443
Protein Name	Glutamate dehydrogenase 1, mitochondrial
Gene Name	Glud1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
363	GSILGFPKAKVYEGS
480	SLERKFGKHGGTIPV
90	DKLVEDLKTRESEEQ

Function

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate (PubMed:20670938). Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (PubMed:16959573). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)

Protein Sequence

10 MYRRLGEALL 20 LSRAGPAALG 30 SAAADSAALL 40 GWARGQPSAA 50 PQPGLTPVAR 60 RHYSEAAADR 70 EDDPNFFKMV 80 EGFFDRGASI 90 VEDKLVEDLK 100 TRESEEQKRN 110 RVRGILRIIK 120 PCNHVLSLSF 130 PIRRDDGSWE 140 VIEGYRAQHS 150 QHRTPCKGGI 160 RYSTDVSVDE 170 VKALASLMTY 180 KCAVVDVPFG 190 GAKAGVKINP 200 KNYTDNELEK 210 ITRRFTMELA 220 KKGFIGPGID 230 VPAPDMSTGE 240 REMSWIADTY 250 ASTIGHYDIN 260 AHACVTGKPI 270 SQGGIHGRIS 280 ATGRGVFHGI 290 ENFINEASYM 300 SILGMTPGFG 310 DKTFVVQGFG 320 NVGLHSMRYL 330 HRFGAKCVGV 340 GESDGSIWNP 350 DGIDPKELED 360 FKLQHGSILG 370 FPKAKVYEGS 380 ILEADCDILI 390 PAASEKQLTK 400 SNAPRVKAKI 410 IAEGANGPTT 420 PEADKIFLER 430 NIMVIPDLYL 440 NAGGVTVSYF 450 EWLKNLNHVS 460 YGRLTFKYER 470 DSNYHLLMSV 480 QESLERKFGK 490 HGGTIPVVPT 500 AEFQDRISGA 510 SEKDIVHSGL 520 AYTMERSARQ 530 IMRTAMKYNL 540 GLDLRTAAYV 550 NAIEKVFKVY NEAGVTFT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity
Molecular Function	GO:0004354	glutamate dehydrogenase (NADP+) activity
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0070728	L-leucine binding
Molecular Function	GO:0070403	NAD+ binding
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:0006541	glutamine metabolic process
Biological Process	GO:0006538	L-glutamate catabolic process
Biological Process	GO:0032024	positive regulation of insulin secretion
Biological Process	GO:0010044	response to aluminum ion
Biological Process	GO:0072350	tricarboxylic acid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.