Search Results

Overview

Uniprot IDP26640
Protein NameValine--tRNA ligase
Gene NameVARS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1230 AASGYPVKVPLEVQE
229 PEAPALPKTAAQLKK
246 KKREKLEKFQQKQKI
252 EKFQQKQKIQQQQPP
263 QQPPPGEKKPKPEKR
432 DRIYHQLKKLGSSLD
507 LLSVPGYKEKVEFGV
638 LPRFEARKAVLVALK
645 KAVLVALKERGLFRG
769 EAREKAAKEFGVSPD

Function

Catalyzes the attachment of valine to tRNA(Val)

Protein Sequence

10 MSTLYVSPHP 20 DAFPSLRALI 30 AARYGEAGEG 40 PGWGGAHPRI 50 CLQPPPTSRT 60 PFPPPRLPAL 70 EQGPGGLWVW 80 GATAVAQLLW 90 PAGLGGPGGS 100 RAAVLVQQWV 110 SYADTELIPA 120 ACGATLPALG 130 LRSSAQDPQA 140 VLGALGRALS 150 PLEEWLRLHT 160 YLAGEAPTLA 170 DLAAVTALLL 180 PFRYVLDPPA 190 RRIWNNVTRW 200 FVTCVRQPEF 210 RAVLGEVVLY 220 SGARPLSHQP 230 GPEAPALPKT 240 AAQLKKEAKK 250 REKLEKFQQK 260 QKIQQQQPPP 270 GEKKPKPEKR 280 EKRDPGVITY 290 DLPTPPGEKK 300 DVSGPMPDSY 310 SPRYVEAAWY 320 PWWEQQGFFK 330 PEYGRPNVSA 340 ANPRGVFMMC 350 IPPPNVTGSL 360 HLGHALTNAI 370 QDSLTRWHRM 380 RGETTLWNPG 390 CDHAGIATQV 400 VVEKKLWREQ 410 GLSRHQLGRE 420 AFLQEVWKWK 430 EEKGDRIYHQ 440 LKKLGSSLDW 450 DRACFTMDPK 460 LSAAVTEAFV 470 RLHEEGIIYR 480 STRLVNWSCT 490 LNSAISDIEV 500 DKKELTGRTL 510 LSVPGYKEKV 520 EFGVLVSFAY 530 KVQGSDSDEE 540 VVVATTRIET 550 MLGDVAVAVH 560 PKDTRYQHLK 570 GKNVIHPFLS 580 RSLPIVFDEF 590 VDMDFGTGAV 600 KITPAHDQND 610 YEVGQRHGLE 620 AISIMDSRGA 630 LINVPPPFLG 640 LPRFEARKAV 650 LVALKERGLF 660 RGIEDNPMVV 670 PLCNRSKDVV 680 EPLLRPQWYV 690 RCGEMAQAAS 700 AAVTRGDLRI 710 LPEAHQRTWH 720 AWMDNIREWC 730 ISRQLWWGHR 740 IPAYFVTVSD 750 PAVPPGEDPD 760 GRYWVSGRNE 770 AEAREKAAKE 780 FGVSPDKISL 790 QQDEDVLDTW 800 FSSGLFPLSI 810 LGWPNQSEDL 820 SVFYPGTLLE 830 TGHDILFFWV 840 ARMVMLGLKL 850 TGRLPFREVY 860 LHAIVRDAHG 870 RKMSKSLGNV 880 IDPLDVIYGI 890 SLQGLHNQLL 900 NSNLDPSEVE 910 KAKEGQKADF 920 PAGIPECGTD 930 ALRFGLCAYM 940 SQGRDINLDV 950 NRILGYRHFC 960 NKLWNATKFA 970 LRGLGKGFVP 980 SPTSQPGGHE 990 SLVDRWIRSR 1000 LTEAVRLSNQ 1010 GFQAYDFPAV 1020 TTAQYSFWLY 1030 ELCDVYLECL 1040 KPVLNGVDQV 1050 AAECARQTLY 1060 TCLDVGLRLL 1070 SPFMPFVTEE 1080 LFQRLPRRMP 1090 QAPPSLCVTP 1100 YPEPSECSWK 1110 DPEAEAALEL 1120 ALSITRAVRS 1130 LRADYNLTRI 1140 RPDCFLEVAD 1150 EATGALASAV 1160 SGYVQALASA 1170 GVVAVLALGA 1180 PAPQGCAVAL 1190 ASDRCSIHLQ 1200 LQGLVDPARE 1210 LGKLQAKRVE 1220 AQRQAQRLRE 1230 RRAASGYPVK 1240 VPLEVQEADE 1250 AKLQQTEAEL 1260 RKVDEAIALF QKML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004832 valine-tRNA ligase activity
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Biological Process GO:0006438 valyl-tRNA aminoacylation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.