Search Results

Overview

Uniprot IDP26641
Protein NameElongation factor 1-gamma
Gene NameEEF1G
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 KQATENAKEEVRRIL
147 GLLDAYLKTRTFLVG
212 GEVKLCEKMAQFDAK
219 KMAQFDAKKFAETQP
220 MAQFDAKKFAETQPK
227 KFAETQPKKDTPRKE
228 FAETQPKKDTPRKEK
241 EKGSREEKQKPQAER
243 GSREEKQKPQAERKE
253 AERKEEKKAAAPAPE
277 LAAEPKAKDPFAHLP
294 TFVLDEFKRKYSNED
401 YESYTWRKLDPGSEE
434 GKAFNQGKIFK****

Function

Probably plays a role in anchoring the complex to other cellular components

Protein Sequence

10 MAAGTLYTYP 20 ENWRAFKALI 30 AAQYSGAQVR 40 VLSAPPHFHF 50 GQTNRTPEFL 60 RKFPAGKVPA 70 FEGDDGFCVF 80 ESNAIAYYVS 90 NEELRGSTPE 100 AAAQVVQWVS 110 FADSDIVPPA 120 STWVFPTLGI 130 MHHNKQATEN 140 AKEEVRRILG 150 LLDAYLKTRT 160 FLVGERVTLA 170 DITVVCTLLW 180 LYKQVLEPSF 190 RQAFPNTNRW 200 FLTCINQPQF 210 RAVLGEVKLC 220 EKMAQFDAKK 230 FAETQPKKDT 240 PRKEKGSREE 250 KQKPQAERKE 260 EKKAAAPAPE 270 EEMDECEQAL 280 AAEPKAKDPF 290 AHLPKSTFVL 300 DEFKRKYSNE 310 DTLSVALPYF 320 WEHFDKDGWS 330 LWYSEYRFPE 340 ELTQTFMSCN 350 LITGMFQRLD 360 KLRKNAFASV 370 ILFGTNNSSS 380 ISGVWVFRGQ 390 ELAFPLSPDW 400 QVDYESYTWR 410 KLDPGSEETQ 420 TLVREYFSWE 430 GAFQHVGKAF NQGKIFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0009615 response to virus
Biological Process GO:0006414 translational elongation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[12] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[13] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.