Search Results
Overview
| Uniprot ID | P26883 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP1A |
| Gene Name | Fkbp1a |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | PFKFTLGKQEVIRGW |
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)
Protein Sequence
10
MGVQVETISP
20
GDGRTFPKRG
30
QTCVVHYTGM
40
LEDGKKFDSS
50
RDRNKPFKFT
60
LGKQEVIRGW
70
EEGVAQMSVG
80
QRAKLIISSD
90
YAYGATGHPG
100
IIPPHATLVF
DVELLKLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098562 | cytoplasmic side of membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:1990425 | ryanodine receptor complex |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0070697 | activin receptor binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0005528 | FK506 binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0070411 | I-SMAD binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
| Molecular Function | GO:0005160 | transforming growth factor beta receptor binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0034713 | type I transforming growth factor beta receptor binding |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0031000 | response to caffeine |
| Biological Process | GO:0042098 | T cell proliferation |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.