Search Results

Overview

Uniprot IDP27139
Protein NameCarbonic anhydrase 2
Gene NameCa2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
113 EHTVNKKKYAAELHL
167 TEALHSIKTKGKRAA
251 WRPAQPLKNRKIKAS

Function

Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (PubMed:9665810). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity)

Protein Sequence

10 MSHHWGYSKS 20 NGPENWHKEF 30 PIANGDRQSP 40 VDIDTGTAQH 50 DPSLQPLLIC 60 YDKVASKSIV 70 NNGHSFNVEF 80 DDSQDFAVLK 90 EGPLSGSYRL 100 IQFHFHWGSS 110 DGQGSEHTVN 120 KKKYAAELHL 130 VHWNTKYGDF 140 GKAVQHPDGL 150 AVLGIFLKIG 160 PASQGLQKIT 170 EALHSIKTKG 180 KRAAFANFDP 190 CSLLPGNLDY 200 WTYPGSLTTP 210 PLLECVTWIV 220 LKEPITVSSE 230 QMSHFRKLNF 240 NSEGEAEELM 250 VDNWRPAQPL 260 KNRKIKASFK

Gene Ontology

Classification GO ID Description
Biological Process GO:0045124 regulation of bone resorption
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0030424 axon
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005902 microvillus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004064 arylesterase activity
Molecular Function GO:0004089 carbonate dehydratase activity
Molecular Function GO:0018820 cyanamide hydratase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0038166 angiotensin-activated signaling pathway
Biological Process GO:0015670 carbon dioxide transport
Biological Process GO:0071498 cellular response to fluid shear stress
Biological Process GO:0044849 estrous cycle
Biological Process GO:0001822 kidney development
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0045780 positive regulation of bone resorption
Biological Process GO:0032849 positive regulation of cellular pH reduction
Biological Process GO:2001150 positive regulation of dipeptide transmembrane transport
Biological Process GO:0045672 positive regulation of osteoclast differentiation
Biological Process GO:0030641 regulation of cellular pH
Biological Process GO:0051453 regulation of intracellular pH
Biological Process GO:0044070 regulation of monoatomic anion transport
Biological Process GO:0043627 response to estrogen
Biological Process GO:1904404 response to formaldehyde
Biological Process GO:0009268 response to pH
Biological Process GO:0048545 response to steroid hormone
Biological Process GO:0010043 response to zinc ion

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.